Aminothiazole
Based on 2 publication(s) in Google Scholar
Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators.
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- Purity: 99.82%
- CAS No.: 96-50-4
- 화학식: C3H4N2S
- 분자량:100.14
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Publications Citing Use of MedChemExpress (MCE) Aminothiazole
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Biological Activity
Aminothiazole can be used as a thyroid inhibitor in the research of hyperthyroidism and it has antibacterial activity[1].
Aminothiazole can be used for the synthesis of antitubercular and antibacterial agents[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 96-50-4
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Appearance Solid
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분자량 100.14
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화학식 C3H4N2S
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Color Light yellow to khaki
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SMILES
NC1=NC=CS1
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Synonyms
2-Aminothiazole; 2-Thiazolylamine
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380 -
용액&용해도
H2O : ≥ 100 mg/mL (998.60 mM)
DMSO : ≥ 50 mg/mL (499.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (24.97 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (24.97 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (275 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Gallardo-Godoy A, et al. 2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24;54(4):1010-21. [Content Brief]
[2]. Khalifa ME, et, al. Recent Developments and Biological Activities of 2-Aminothiazole Derivatives. Acta Chim Slov. 2018 Mar;65(1):1-22. [Content Brief]
[3]. Ran K, et, al. Identification of novel 2-aminothiazole conjugated nitrofuran as antitubercular and antibacterial agents. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3669-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 9.9860 mL | 49.9301 mL | 99.8602 mL | 249.6505 mL |
| 5 mM | 1.9972 mL | 9.9860 mL | 19.9720 mL | 49.9301 mL | |
| 10 mM | 0.9986 mL | 4.9930 mL | 9.9860 mL | 24.9650 mL | |
| 15 mM | 0.6657 mL | 3.3287 mL | 6.6573 mL | 16.6434 mL | |
| 20 mM | 0.4993 mL | 2.4965 mL | 4.9930 mL | 12.4825 mL | |
| 25 mM | 0.3994 mL | 1.9972 mL | 3.9944 mL | 9.9860 mL | |
| 30 mM | 0.3329 mL | 1.6643 mL | 3.3287 mL | 8.3217 mL | |
| 40 mM | 0.2497 mL | 1.2483 mL | 2.4965 mL | 6.2413 mL | |
| 50 mM | 0.1997 mL | 0.9986 mL | 1.9972 mL | 4.9930 mL | |
| 60 mM | 0.1664 mL | 0.8322 mL | 1.6643 mL | 4.1608 mL | |
| 80 mM | 0.1248 mL | 0.6241 mL | 1.2483 mL | 3.1206 mL | |
| 100 mM | 0.0999 mL | 0.4993 mL | 0.9986 mL | 2.4965 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Aminothiazole Related Classifications
HY-12396 Related Classifications
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