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Cat. No.: HY-16308

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FBPase-IN-5

Name: FBPase-IN-5
Brand: MedChemExpress
SKU: HY-16308
Price: 455.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

MB-07729 is a potent fructose 1,6-bisphosphatase (FBPase) noncompetitive inhibitor with IC₅₀ values of 31, 121, and 189 nM for human, monkey, and rat, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 99.31%
CAS No.: 882755-95-5
화학식: C₁₂H₁₅N₂O₅PS
분자량:330.30

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

FBPase-IN-5 Chemical Structure

CAS No.: 882755-95-5

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

MB-07729 is a potent fructose 1,6-bisphosphatase (FBPase) noncompetitive inhibitor with IC₅₀ values of 31, 121, and 189 nM for human, monkey, and rat, respectively.

IC₅₀ & Target

IC50: 31 nM (human), 121nM (monkey), and 189 nM (rat)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	EC₅₀	140 nM Compound: MB07729	Inhibition of glucose production in human hepatocyte assessed as reduction in blood glucose level Inhibition of glucose production in human hepatocyte assessed as reduction in blood glucose level	[PMID: 29055870]

Chemical Information

CAS No. 882755-95-5
Appearance Solid
분자량 330.30
화학식 C₁₂H₁₅N₂O₅PS
Color White to off-white
SMILES

CC(C)(C)C(C1=C(C2=CC=C(P(O)(O)=O)O2)N=C(N)S1)=O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. PAUL D. VAN POELJE，et al. MB07803, a Prodrug of a Second Generation Fructose-1,6-Bisphosphatase Inhibitor, Lowers Blood Glucose in Diabetic Rodents and in Cynomolgus Monkeys.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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