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Cat. No.: HY-16309

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MB-07803

MB-07803 is an orally active fructose-1,6-bisphosphatase (FBP1) inhibitor and a derivative of CS-917 (HY-14955). MB-07803 inhibits the rate-limiting enzyme in gluconeogenesis. MB07803 is converted as a prodrug to the active metabolite MB07729. MB-07803 controls blood glucose and is used in research on type 2 diabetes.

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CAS No.: 882757-24-6
화학식: C₂₄H₃₇N₄O₇PS
분자량:556.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (289 KB)

MB-07803 Chemical Structure

CAS No.: 882757-24-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

31, 121, 189 nM for human, monkey, and rat, respectively^[1].

In Vitro

MB-07803 is a derivative of CS-917 (HY-14955) and an FBP1 inhibitor with improved pharmacokinetic profiles, higher oral bioavailability, a longer half-life of the active metabolite, and less formation of inactive N-acetylated metabolites, and it reduces fasting blood glucose in a dose-dependent manner^[1].
MB-07803 is a prodrug form of an FBP1 inhibitor and a CS‑917 derivative that can be converted to generate the active metabolite MB07729^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Metabolic Diseases

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS No. 882757-24-6
분자량 556.61
화학식 C₂₄H₃₇N₄O₇PS
SMILES

O=C(C(C)(C)NP(NC(C)(C)C(OCC)=O)(C1=CC=C(C2=C(C(C(C)(C)C)=O)SC(N)=N2)O1)=O)OCC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (289 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen W, et al. The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7. Cardiovascular diabetology. 2024 Jan 09;23(1):21. [Content Brief]

[2]. Sawant S D, et al. Comprehensive Review and Perspective on Fructose 1, 6-Bisphosphatase Inhibitors for the Management of Type 2 Diabetes Mellitus[J]. Russian Journal of Bioorganic Chemistry, 2025, 51(2): 439-464.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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