MK-3328
Based on 1 Customer Validation
MK-3328 is a β-Amyloid ligand, which exhibits high binding potency with an IC50 of 10.5 nM. MK-3328 is capable of being labelled with 18F for positron emission tomography (PET) imaging.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.70%
- CAS No.: 1201323-97-8
- 화학식: C14H9FN4O
- 분자량:268.25
-
보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocol
- 순도&문서
- References
-
Help & FAQs
-
HY-105252A
BF 227 -
HY-P1363A
β-Amyloid (1-42), humanAmyloid β Peptide -
HY-P1363B
β-Amyloid (1-42), human, HFIP-treatedβ-Amyloid (1-42) Peptide -
HY-19370
FPS-ZM1Amyloid-β Inhibitor -
HY-18292
ARN2966APP Translation Modulator -
HY-111267
Aftin-4Amyloid-β Agonist -
HY-17631A
Edonerpic maleate -
HY-15374
FrentizoleAβ-ABAD Inbihitor -
HY-19771
GSK 3039294Miridesap Pro-drug -
HY-14503
MDR-1339Amyloid-β Inhibitor -
HY-14533
K 01-162Aβ Inhibitor -
HY-50900
gamma-Secretase ModulatorsAmyloid-β Inhibitor
Biological Activity
제품 설명
IC50 & Target
IC50: 10.5 nM (β-Amyloid)[1]
In Vitro
MK-3328 exhibits amyloid binding potency balanced with low levels of nonspecific binding[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1201323-97-8
-
Appearance Solid
-
분자량 268.25
-
화학식 C14H9FN4O
-
Color Off-white to light brown
-
SMILES
CN1C=CC2=CC(C3=NC4=CC=C(F)N=C4O3)=CN=C21
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서
-
Data Sheet (272 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Harrison ST, et al. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011 Apr 18;2(7):498-502. [Content Brief]
[2]. Hostetler ED, et al. [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey. Nucl Med Biol. 2011 Nov;38(8):1193-203. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MK-3328 Related Classifications
HY-100275 Related Classifications
Powered by Bioz