PDM2
Based on 3 publication(s) in Google Scholar
PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an Ki of 1.2±0.4 nM.
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- Purity: 98.96%
- CAS No.: 688348-25-6
- 화학식: C14H9Cl3
- 분자량:283.58
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PDM2
More
Biological Activity
Ki: 1.2±0.4 nM(AhR)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>30 μM
Compound: 4i
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Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay
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[PMID: 28576617] |
| HEK293 | IC50 |
>30 μM
Compound: 4i
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Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addition measured for 1 min by Fluo-4 dye-based assay
Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addition measured for 1 min by Fluo-4 dye-based assay
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[PMID: 28576617] |
PDM2 (Compound 4b) exhibits a Ki of 1.2±0.4 nM for AhR and no affinity for estrogen receptor (ER), confirming that replacement of hydroxyl with chloride abolished binding on ER and increased dramatically the affinity for AhR[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 688348-25-6
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Appearance Solid
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분자량 283.58
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화학식 C14H9Cl3
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Color White to off-white
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SMILES
ClC1=CC=C(/C=C/C2=CC(Cl)=CC(Cl)=C2)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Environ Pollut
Iron-doped diesel exhaust early-in-life inhalation-induced cardiopulmonary toxicity in chicken embryo: Roles of ferroptosis and acyl hydrocarbon signaling. [Abstract]2024 Oct 5;363(Pt 1):125085. PMID: 39374763 -
Front Microbiol
Fine Particulate Matter (PM2.5) Promotes CD146 Expression in Alveolar Epithelial Cells and Cryptococcus neoformans Pulmonary Infection. [Abstract]2021 Jan 18:11:525976. PMID: 33537006 -
Front Oncol
Cancer Associated Fibroblasts Promote Renal Cancer Progression Through a TDO/Kyn/AhR Dependent Signaling Pathway. [Abstract]2021 Mar 25:11:628821. PMID: 33842334
용액&용해도
DMSO : 50 mg/mL (176.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (271 KB)
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SDS (698 KB)
- English - EN (698 KB)
- Français - FR (698 KB)
- Deutsch - DE (698 KB)
- Norwegian - NO (698 KB)
- Español - ES (698 KB)
- Swedish - SV (698 KB)
- Italian - IT (698 KB)
- Portuguese - PT (698 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5263 mL | 17.6317 mL | 35.2634 mL | 88.1585 mL |
| 5 mM | 0.7053 mL | 3.5263 mL | 7.0527 mL | 17.6317 mL | |
| 10 mM | 0.3526 mL | 1.7632 mL | 3.5263 mL | 8.8159 mL | |
| 15 mM | 0.2351 mL | 1.1754 mL | 2.3509 mL | 5.8772 mL | |
| 20 mM | 0.1763 mL | 0.8816 mL | 1.7632 mL | 4.4079 mL | |
| 25 mM | 0.1411 mL | 0.7053 mL | 1.4105 mL | 3.5263 mL | |
| 30 mM | 0.1175 mL | 0.5877 mL | 1.1754 mL | 2.9386 mL | |
| 40 mM | 0.0882 mL | 0.4408 mL | 0.8816 mL | 2.2040 mL | |
| 50 mM | 0.0705 mL | 0.3526 mL | 0.7053 mL | 1.7632 mL | |
| 60 mM | 0.0588 mL | 0.2939 mL | 0.5877 mL | 1.4693 mL | |
| 80 mM | 0.0441 mL | 0.2204 mL | 0.4408 mL | 1.1020 mL | |
| 100 mM | 0.0353 mL | 0.1763 mL | 0.3526 mL | 0.8816 mL |
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