PNU-103017
PNU-103017 is an HIV protease inhibitor.
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- CAS No.: 166335-18-8
- 화학식: C28H28N2O5S
- 분자량:504.60
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
HIV protease[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H9 | ED50 |
1.3 μM
Compound: 35k
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Antiviral activity in HIV-1 infected H9 cells
Antiviral activity in HIV-1 infected H9 cells
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[PMID: 9089336] |
| H9 | IC50 |
1.5 μM
Compound: 1e
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Antiviral activity against HIV-1 IIIB in H9 (human leukemia) cells.
Antiviral activity against HIV-1 IIIB in H9 (human leukemia) cells.
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10.1016/S0960-894X(97)00031-0 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 166335-18-8
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분자량 504.60
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화학식 C28H28N2O5S
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SMILES
O=S(C1=CC=C(C#N)C=C1)(NC2=CC=CC(C(C3CC3)C4=C(O)C(CCCCCC5)=C5OC4=O)=C2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
Rats and dogs are used in this study. In preclinical toxicology studies, dogs (three per gender per dose) receive 50, 100, 200, or 250 mg/kg/day, and rats (three per gender per dose) receive 80, 240, or 720 mg/kg/day PNU-103017 in a 0.5 N sodium hydroxide aqueous solution orally, twice daily, 8 and 16 h apart, respectively, for 14 days. Sequential blood specimens are collected at 0 (prior to the first daily dosing), 1, 2, 4, 8 (prior to the second daily dosing), 9, 10, 12, 16 (for dog only), and 24 h after the first daily dosing on treatment days 1, 8, and 14 for the dog and rat studies. The samples are placed into heparinized tubes, and the plasma is separated by centrifugation and stored at or below -10°C until analysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PNU-103017 Related Classifications
HY-19236 Related Classifications
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