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Cat. No.: HY-118668

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ABD-350

ABD-350 is an antiresorptive agent that inhibits osteoclast activity without affecting osteoblast activity and preventing ovariectomy-induced bone loss. ABD-350 inhibits NF-κB ligand-induced inhibitor of NF-κB phosphorylation, leading to osteoclast apoptosis, but has no inhibitory effect on osteoblast function, effectively preventing bone loss in ovariectomized mice, and does not inhibit parathyroid hormone-induced bone formation.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1117772-52-7
화학식: C₁₉H₂₂F₂O₂
분자량:320.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

ABD-350 Chemical Structure

CAS No.: 1117772-52-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
J774	IC₅₀	8 μM Compound: 3u	Cytotoxicity against mouse J774 cells expressing RANKL signaling by Alamar blue assay Cytotoxicity against mouse J774 cells expressing RANKL signaling by Alamar blue assay	[PMID: 20692834]
Osteoblast	IC₅₀	>100 μM Compound: 3u	Cytotoxicity against mouse osteoblast cells by alamar blue assay Cytotoxicity against mouse osteoblast cells by alamar blue assay	[PMID: 20692834]
Osteoclast	IC₅₀	1.3 μM Compound: 3u	Cytotoxicity against mouse osteoclast cells expressing RANKL signaling by Alamar blue assay Cytotoxicity against mouse osteoclast cells expressing RANKL signaling by Alamar blue assay	[PMID: 20692834]

Chemical Information

CAS No. 1117772-52-7
분자량 320.37
화학식 C₁₉H₂₂F₂O₂
SMILES

OC(CCCCCO)C1=CC=C(C(C)=C1)C2=CC=C(C=C2F)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Identification of novel biphenyl carboxylic acid derivatives as novel antiresorptive agents that do not impair parathyroid hormone-induced bone formation [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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