AC 187
Based on 1 Customer Validation
AC 187 is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.57%
- CAS No.: 151804-77-2
- 화학식: C127H205N37O40
- 분자량:2890.21
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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HY-P1070
Amylin, amide, humanGlucoregulatory Hormone -
HY-P0058
PramlintideAnti-diabetic Agent -
HY-P2273
Calcitonin (human)Hypocalcemic Hormone -
HY-P3462
CagrilintideAMYR/CTR agonist -
HY-P0090
Calcitonin (salmon)CGRP Receptor Agonist -
HY-P1071
α-CGRP (human)Vasodilator -
HY-P1464
Amylin, amide, ratAMY1/AMY3 Ligand -
HY-P1782
Calcitonin (8-32), salmonAmylin Receptor Antagonist -
HY-P0209
Rat CGRP-(8-37)CGRP Receptor Antagonist -
HY-P1014
HCGRP-(8-37)CGRP Receptor Antagonist -
HY-P0203
α-CGRP (mouse, rat)Neuropeptide -
HY-103302
SUN B8155Calcitonin Receptor Agonist
Biological Activity
제품 설명
IC50 & Target
IC50: 0.48 nM (amylin receptor)
In Vitro
AC 187 blocks amyloidβ protein (Aβ)-induced neurotoxicity. Treatment of cultures with AC 187 before exposure to Aβ results in significantly improved neuronal survival[1].
AC187 attenuates the activation of initiator and effector caspases that mediate Aβ-induced apoptotic cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 151804-77-2
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Appearance Solid
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분자량 2890.21
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화학식 C127H205N37O40
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Color White to off-white
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Sequence
Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2
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Sequence Shortening
Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
In Vitro:
DMSO : ≥ 100 mg/mL (34.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Jack H Jhamandas, et al. Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci. 2004 Jun 16;24(24):5579-84. [Content Brief]
[2]. Bronislava R Gedulin, et al. Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul Pept. 2006 Dec 10;137(3):121-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3460 mL | 1.7300 mL | 3.4600 mL | 8.6499 mL |
| 5 mM | 0.0692 mL | 0.3460 mL | 0.6920 mL | 1.7300 mL | |
| 10 mM | 0.0346 mL | 0.1730 mL | 0.3460 mL | 0.8650 mL | |
| 15 mM | 0.0231 mL | 0.1153 mL | 0.2307 mL | 0.5767 mL | |
| 20 mM | 0.0173 mL | 0.0865 mL | 0.1730 mL | 0.4325 mL | |
| 25 mM | 0.0138 mL | 0.0692 mL | 0.1384 mL | 0.3460 mL | |
| 30 mM | 0.0115 mL | 0.0577 mL | 0.1153 mL | 0.2883 mL |
AC 187 Related Classifications
HY-P1393 Related Classifications
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