AChE-IN-15
AChE-IN-15 (Compound 3d) is a reversible human acetylcholinesterase (huAChE) (IC50=6.8 μM) and human butyrylcholinesterase (huBChE) (IC50=16.1 μM) inhibitor. AChE-IN-15 shows significant antioxidant potency, AChE-IN-15 can be used for the research of Alzheimer’s disease.
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- CAS No.: 2242792-25-0
- 화학식: C23H24N2O7
- 분자량:440.45
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
AChE-IN-15 (compound 3d) inhibits huAChE and huBChE with IC50 values of 6.8 and 16.1 μM and inhibits RatAChE and RatBChE with IC50 values of 4.7 and 12.1μM[1].
AChE-IN-15 (compound 3d) (25 μM) inhibits self-mediated aggregation (77.9), huAChE-induced Aβ1-42 aggregation (73.6%), inhibit (78.9%) and disaggregate (64.6%) Cu2+-mediated Cu2+-mediated aggregation[1].
AChE-IN-15 (compound 3d) (25 μM) is an neuroprotective agent and displays hepatoprotective activity[1].
AChE-IN-15 (compound 3d) (25 μM) shows good blood-brain barrier (BBB) penetration[1].
AChE-IN-15 (compound 3d) (5-10 μM) displays neuroprotective effect on Aβ1-42-induced SH-SY5Y neurotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells
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Concentration:5 and 10 μM
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Incubation Time:24 hours
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Result:Increased the cell viability to 63.9% (5 μM) and 72.3% (10 μM), respectively.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice[1]
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Dosage:5, 10 and 20 mg/kg
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Administration:for 14 days
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Result:Reversed cognitive deficit induced by scopolamine.
Chemical Information
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CAS No. 2242792-25-0
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분자량 440.45
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화학식 C23H24N2O7
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SMILES
O=C(OC1=CC=C(C2=CC(C3=C(O)C=C(OC(N(CC)C)=O)C=C3O2)=O)C=C1)N(CC)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-15 Related Classifications
HY-146039 Related Classifications
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