AI10-a2
AI10-a2 is a tyrosinase (tyrosinase) inhibitor, with IC50 values of 0.92 μM against mushroom tyrosinase using L-DOPA (HY-N0304) as the substrate and 0.68 μM using L-Tyrosine (HY-N0473) as the substrate. AI10-a2 inhibits intracellular melanin (melanin) production and reduces head pigmentation in zebrafish embryos. AI10-a2 can be used for the research of hyperpigmentation disorders.
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- 화학식: C19H23N3O3
- 분자량:341.40
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
AI10-a2 (12.5-100 μM) inhibits melanogenesis in B16F10 cells stimulated by Melanotan (MT)-II (HY-P0267) in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild-type AB strain (embryos at 6 h postfertilization)[1]
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Dosage:30 μM; 60 μM
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Administration:immersion; continuous; 45 h
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Result:Achieved a depigmentation efficacy of 12.68% at 60 μM.
Showed minimal to negligible toxicity in treated embryos.
Chemical Information
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분자량 341.40
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화학식 C19H23N3O3
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SMILES
CC1=CC(C(N2CCN(CC2)CC3=CC=C(C=C3O)O)=O)=CC(C)=N1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AI10-a2 Related Classifications
HY-184909 Related Classifications
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