Albaconazole
Albaconazole (UR 9825) is a broad-spectrum triazole and oral activity antifungal agent.
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- CAS No.: 187949-02-6
- 화학식: C20H16ClF2N5O2
- 분자량:431.82
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
34.86 μM
Compound: 7
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Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay
Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay
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[PMID: 24564525] |
Albaconazole (UR 9825) shows antifungal activity with MIC50s of ≤0.0002, ≤0.0002, ≤0.0002, 0.06, 0.015, ≤0.0002 mg/L for C. albicans, C. parapsilosis,C. tropicalis, C. glabrata, C. krusei, C. guilliermondii, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:2.5 kg New Zealand White male rabbits[2]
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Dosage:15, 25, 50 mg/kg
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Administration:P.o.; once daily for 10 days
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Result:Showed lower tissue burdens than the control group.S. prolificans was undetectable in the liver, spleen, and lung cultures, attenuated the histopathological severity in the kidney.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 187949-02-6
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분자량 431.82
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화학식 C20H16ClF2N5O2
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SMILES
C[C@@H](N1C(C2=CC=C(Cl)C=C2N=C1)=O)[C@@](O)(C3=C(C=C(C=C3)F)F)CN4C=NC=N4
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Synonyms
UR 9825
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Ramos G, et al. In-vitro comparative activity of UR-9825, itraconazole and fluconazole against clinical isolates of Candida spp. J Antimicrob Chemother. 1999 Aug;44(2):283-6. [Content Brief]
[2]. Capilla J, et al. Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits. Antimicrob Agents Chemother. 2003 Jun;47(6):1948-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Albaconazole Related Classifications
HY-106141 Related Classifications
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