AM4299 A
AM4299 A is a thiol protease inhibitor with IC50 values of 73, 390 and 88 nM against Cathepsin B, Cathepsin L and Papain, respectively. AM4299 A shows low toxicity and favorable biosafety in mice. AM4299 A can be used in studies related to osteoporosis and parasitic diseases.
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- CAS No.: 160825-48-9
- 화학식: C15H26N2O6
- 분자량:330.38
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Cathepsin Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
Cathepsin C 73 nM (IC50) |
cathepsin L 390 nM (IC50) |
papain 88 nM (IC50) |
In Vitro
AM4299 A specifically inhibits purified bovine spleen cathepsin B (IC50 = 7.3 × 10-8 M), human kidney cathepsin L (IC50 = 3.9 × 10-7 M), and Carica papaya papain (IC50 = 8.8 × 10-8 M), with no activity against bovine pancreas trypsin or α-chymotrypsin at concentrations up to 8.0 × 10-5 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 160825-48-9
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분자량 330.38
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화학식 C15H26N2O6
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SMILES
C(N[C@H](C(NCCCCCO)=O)CC(C)C)(=O)C1C(C(O)=O)O1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AM4299 A Related Classifications
HY-187615 Related Classifications
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