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Cat. No.: HY-179486

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Anticancer agent 285

Anticancer agent 285 is an orally active anticancer agent with highly effective and selective haspin-inhibiting IC₅₀ = 18 nM) activity. Anticancer agent 285 can be used for the study of colorectal cancer_[1].

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CAS No.: 2878446-03-6
화학식: C₁₂H₁₄N₆O₂S
분자량:306.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Anticancer agent 285 Chemical Structure

CAS No.: 2878446-03-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

haspin

18 nM (IC₅₀)

In Vitro

Anticancer agent 285 (Compound 1d) (72 h) exhibits IC₅₀ values of 3.31 μM in SK-Hep-1 cells, 3.91 μM in MDA-MB-231 cells, 4.82 μM in HCT116 cells, 19.7 μM in A549 cells, and 3.58 μM in SNU-638 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anticancer agent 285 (Compound 1d) (10 mg/kg, p.o./i.p., three times per week for 23 days) significantly inhibits tumor growth in a human colorectal cancer cell line (HCT116 cells) xenograft mouse model without showing significant toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HCT116 cells (7 × 10⁶ cells per mouse) were injected subcutaneously into the flanks of the Male Balb/c-nu mice (male, aged 4 weeks)^[1].
Dosage:

10 mg/kg
Administration:

P.o., i.p., three times per week for 23 days
Result:

The oral administration resulted in a tumor inhibition rate of 51.7%.
The intraperitoneal injection resulted in a tumor inhibition rate of 46.2%.
No significant weight loss or obvious toxicity symptoms were observed in any of the mice.

Chemical Information

CAS No. 2878446-03-6
분자량 306.34
화학식 C₁₂H₁₄N₆O₂S
SMILES

O[C@@H]1[C@H](O)[C@@H](CN)S[C@H]1N(C2=C3C(N)=NC=N2)C=C3C#N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yum YA, et al. Design and development of 5'-modified 7-substituted 4'-thionucleosides as potent Haspin inhibitors: Synthesis and biological evaluation. Bioorg Chem. 2025 Nov;166:109146. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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