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Cat. No.: HY-146389

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Anticancer agent 50

Anticancer agent 50 (compound 6) is a potent ABCB1 efflux pump modulator. Anticancer agent 50 shows cytotoxic effects and antiproliferative effects. Anticancer agent 50 decreases the expression of cyclin D1 and induces p53 expression. Anticancer agent 50 has the potential for the research of T-lymphoma.

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CAS No.: 2487457-15-6
화학식: C₃₀H₃₂N₂O₄Se
분자량:563.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 50 Chemical Structure

CAS No.: 2487457-15-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Anticancer agent 50 (compound 6) (0-100 µM) shows cytotoxic effects with IC₅₀s of 0.67, 0.90 µM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively^[1].
Anticancer agent 50 (0-100 µM) shows antiproliferative effects with IC₅₀s of 3.84, 1.34 µM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively^[1].
Anticancer agent 50 (0.1, 0.5, 2 µM; 24 h) inhibits cell cycle progression through the reduction of the expression of cyclin D1 and inhibits cell proliferation by inducing p53 expression^[1].
Anticancer agent 50 (0.1, 0.5, 2, 10 µM; 72 h) inhibits cell growth by 12% in SH-SY5Y cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

JURKAT cells
Concentration:

0.1, 0.5, 2 µM
Incubation Time:

24 h
Result:

Significantly reduced cyclin D1 expression and increased the level of p53.

Chemical Information

CAS No. 2487457-15-6
분자량 563.55
화학식 C₃₀H₃₂N₂O₄Se
SMILES

COC(CN1C(N(C(C2=CC=CC=C2)(C1=O)C3=CC=CC=C3)CCCCCC[Se]C4=CC=CC=C4)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ali W, et al. Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma. Eur J Med Chem. 2020 Aug 15;200:112435. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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