Apoptosis inducer 41
Apoptosis inducer 41 is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 41 exhibits remarkable inhibitory effects against MCF-7 cells (IC50 = 6.2 μM). Apoptosis inducer 41 significantly arrests MCF-7 cells in the G2/M phase, increases ROS accumulation, induces mitochondrial membrane potential depolarization. Apoptosis inducer 41 can used for the study of breast cancer.
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- CAS No.: 3085940-57-1
- 화학식: C39H53BrN4O4
- 분자량:721.77
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
제품 설명
In Vitro
Apoptosis inducer 41 (Compound 6j) (1‑100 μM, 48 h) exhibits antiproliferative activities in various cells with IC50s of 7.1, 40.9, 6.2 and 46.1 against MDA-MB-231, MDA-MB-468, MCF-7 and MCF-10A cells[1].
Apoptosis inducer 41 (1-9 μM, 24-48 h) significantly induces MCF-7 apoptosis through the mitochondrial apoptosis pathway and arrests cells in the G2/M phase[1].
Apoptosis inducer 41 (1-9 μM, 24 h) induces ROS generation and impaires mitochondrial membrane potential (MMP)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:48 h
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Result:Observed the presence of nuclear collapse and the enhancement of red and bright blue fluorescence.
Increased the early apoptosis rates of MCF-7 cells ranged from 1.92% to 16.87%, while the late apoptosis rates ranged from 0.23% to 19.43%.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:24 h
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Result:Promoted the G2/M phase block in a concentration-dependent manner.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:48 h
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Result:Significantly upregulated the levels of cytochrome c and cleaved caspase 8.
Increased the ratio of cleaved PARP to PARP.
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Cell Line:MCF-7 cells
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Concentration:1, 3 and 9 nM
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Incubation Time:24 h
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Result:Increased the ROS levels by 30.67 %, 65.33 %, and 168.00 %, respectively.
Caused the MMP of MCF-7 cells depolarizes with increasing concentrations, which is characterized by a gradual decrease in the red/green fluorescence ratio.
Chemical Information
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CAS No. 3085940-57-1
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분자량 721.77
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화학식 C39H53BrN4O4
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SMILES
C[C@@]12[C@](C[C@@]3([H])[C@]2([H])[C@@H]([C@H](O3)CC[C@@H](C)C(NCC4=CN(N=N4)CC5=CC=C(C=C5)Br)=O)C)([H])[C@@]6([H])[C@]([C@@]7(C(C[C@H](CC7)OC(C)=O)=CC6)C)([H])CC1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 41 Related Classifications
HY-175567 Related Classifications
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