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Cat. No.: HY-114602

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AR-C117977

AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse.

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CAS No.: 216685-07-3
화학식: C₂₅H₂₈N₂O₃S₂
분자량:468.63

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AR-C117977 Chemical Structure

CAS No.: 216685-07-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
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Classifications
Bioz

Biological Activity

제품 설명

All Monocarboxylate Transporter Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against HEK293 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against HEK293 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
HT-29	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
HUVEC	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human HUVEC assessed as inhibition of basic FGF-stimulated cell proliferation by fluorimetric assay Antiproliferative activity against human HUVEC assessed as inhibition of basic FGF-stimulated cell proliferation by fluorimetric assay	[PMID: 16370372]
HUVEC	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human HUVEC assessed as inhibition of acidic FGF-stimulated cell proliferation by fluorimetric assay Antiproliferative activity against human HUVEC assessed as inhibition of acidic FGF-stimulated cell proliferation by fluorimetric assay	[PMID: 16370372]
K562	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
Keratinocyte	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human primary epidermal keratinocytes assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human primary epidermal keratinocytes assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
PANC-1	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
SW480	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
T-24	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human T24 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human T24 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
THP-1	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human THP1 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human THP1 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]
ZR-75-1	IC₅₀	>1000 nM Compound: 1	Antiproliferative activity against human ZR-75-1 cells assessed as inhibition of cell proliferation by fluorimetric assay Antiproliferative activity against human ZR-75-1 cells assessed as inhibition of cell proliferation by fluorimetric assay	[PMID: 16370372]

Chemical Information

CAS No. 216685-07-3
분자량 468.63
화학식 C₂₅H₂₈N₂O₃S₂
SMILES

O=C1N(CC(C)C)C2=C(C(SCCCO)=C(CC3=C4C=CC=CC4=CC=C3)S2)C(N1C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bueno V, et al. The specific monocarboxylate transporter (MCT1) inhibitor, AR-C117977, a novel immunosuppressant, prolongs allograft survival in the mouse. Transplantation. 2007 Nov 15;84(9):1204-7. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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AR-C117977

All Monocarboxylate Transporter Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AR-C117977 Related Classifications

HY-114602 Related Classifications