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Cat. No.: HY-146883

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As-358

As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC₅₀s of 47.5 μM and 3.7 μM.

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CAS No.: 2222042-47-7
화학식: C₁₈H₃₁NO₂
분자량:293.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

As-358 Chemical Structure

CAS No.: 2222042-47-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC₅₀s of 47.5 μM and 3.7 μM^[1].

IC₅₀ & Target

EBOV

MARV

All Filovirus Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	302 μM Compound: 4	Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30108738]
HEK-293T	CC₅₀	289.7 μM Compound: 3b; As-358	Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay	[PMID: 32905862]
MDCK	CC₅₀	69.6 μM Compound: 14	Cytotoxicity against MDCK cells after 48 hrs by MTT assay Cytotoxicity against MDCK cells after 48 hrs by MTT assay	[PMID: 30108810]
Vero	CC₅₀	442.9 μM Compound: 3b; As-358	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis	[PMID: 32905862]

In Vitro

As-358 (compound 3b) (0-500 μM; 10 days) exhibits inhibitory activities against EBOV and MARV^[1].
As-358 (0-100 μM; 48 hours) can inhibit WT-EboV-GP and mutant D522A-EboV-GP, with IC₅₀s of 1.7 and 2.2 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Cell Proliferation Assay

View Protocol

Cell Line:

Vero (infected with EBOV and MARV)^[1]
Concentration:

0-500 μM
Incubation Time:

10 days
Result:

Exhibited inhibitory activities against EBOV and MARV, with IC₅₀s of 47.5 ± 8.2 μM and 3.7 ± 1.7 μM, SI values of 9 and 118, respectively.

Chemical Information

CAS No. 2222042-47-7
분자량 293.44
화학식 C₁₈H₃₁NO₂
SMILES

O=C(O[C@@H]1C[C@@H]2CC[C@]1(C2(C)C)C)CCN3CCCCC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sokolova AS, Yarovaya OI, Zybkina AV, et al. Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process. Eur J Med Chem. 2020;207:112726. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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