AS15
AS15 is a PDIA1 inhibitor with an IC50 value of 300 nM. AS15 interacts with the active-site cysteine of PDIA1, and this process is independent of the substrate-binding domain of PDIA1. AS15 acts as a synergistic cell growth inhibitor with buthionine sulfoximine (BSO) (HY-106376), a glutathione synthesis inhibitor. AS15 can be used in the research of glioblastoma.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 102616-62-6
- 화학식: C20H23NO6
- 분자량:373.40
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
PDIA1 300 nM (IC50) |
AS15 reduces the viability of U-87 MG glioblastoma cells, with an IC50 of 18.3 μM[1].
AS15 (0.3-3 μM; 24 h) reduces the colony-forming ability of U-118 MG glioblastoma cells, and its activity can be enhanced by glutathione depletion via pre-treatment with BSO[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:U-118 MG glioblastoma cells
-
Concentration:0.3, 1 and 3 μM
-
Incubation Time:24 h (BSO pretreatment)
-
Result:Increased potency in reducing colony formation after pretreatment with BSO (a glutathione synthesis inhibitor), supporting that glutathione depletion sensitizes glioblastoma cells to AS15.
Chemical Information
-
CAS No. 102616-62-6
-
분자량 373.40
-
화학식 C20H23NO6
-
SMILES
OC1=C(C(N2CCOCC2)C3=CC=C(C(OC)=C3)OC)C=C4OCOC4=C1
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS15 Related Classifications
HY-183406 Related Classifications
Powered by Bioz