AT-076
AT-076 is an opioid pan antagonist at nociception, kappa, mu, and delta opioid receptors, with Ki values of 1.75 nM (NOP), 1.67 nM (MOP), 1.14 nM (KOP) and 19.6 nM (DOP), respectively.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 1657028-64-2
- 화학식: C26H35N3O3
- 분자량:437.57
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Opioid Receptor Isoforms
More
Biological Activity
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NOP Receptor/ORL1 1.75 nM (IC50) |
μ Opioid Receptor/MOR 1.67 nM (IC50) |
κ Opioid Receptor/KOR 1.14 nM (IC50) |
δ Opioid Receptor/DOR 19.6 nM (IC50) |
Chemical Information
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CAS No. 1657028-64-2
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분자량 437.57
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화학식 C26H35N3O3
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SMILES
OC1=CC=CC(C(CC2)CCN2C[C@H](C(C)C)NC([C@H]3CC4=CC=C(O)C=C4CN3)=O)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Nurulain T Zaveri, et al. Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors. ACS Chem Neurosci. 2015 Apr 15;6(4):646-57. [Content Brief]
[2]. V Blair Journigan, et al. Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships. Sci Rep. 2017 Oct 16;7(1):13255. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AT-076 Related Classifications
HY-106732 Related Classifications
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