AT1412
AT1412 is a CD9-binding antibody. AT1412 binds to the tetraspanin protein CD9 and modulates CD9 function by enhancing T cell adhesion to endothelial cells (HUVECs) and transendothelial migration. AT1412 binds to B-ALL cell lines but not to T-ALL. AT1412 induces antibody-dependent cellular cytotoxicity in B-ALL cell lines. AT1412 binds to melanoma cells, B-ALL, gastric cancer, colorectal cancer, and pancreatic cancer cells [1] .
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Human
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CD9 |
AT1412 binds thetetraspanin CD9, can regulate CD9 function by enhancing T cell adhesion to endothelial cells (HUVECs) and transendothelial migration [2].
AT1412 induces antibody-dependent cytotoxicity in B-ALL cell lines SUP-B15, MHH-CALL-2 and CCRF-SB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Synonyms
AT14-012
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AT1412 Related Classifications
HY-P991896 Related Classifications
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- AT1412
- AT14-012
- AT 1412
- AT-1412
- Transmembrane Glycoprotein
- B-ALL blasts
- antibody dependent cellular cytotoxicity
- A375-CD9KO
- CD8 T-cell
- ICAM-1
- A375 melanoma
- A375wt
- ADCP
- B-ALL
- effector cells
- melanoma cells
- LFA-1
- CD9
- human immune system mouse models
- granulocytic
- VLA-4
- lymphocytic populations
- metastatic melanoma
- T cells
- tetraspanin CD9
- endothelial cells
- colon cancer cells
- ADCC
- monocytic
- HIS mouse models
- nivolumab
- SK-MEL5 melanoma cells
- PD-1 resistant SK-MEL5 melanoma model
- pancreatic cancer cells
- gastric cancer cells
- HUVEC cells
- antibody-dependent cellular phagocytosis
- NSG mice
- cd9 positive precursor b-acute lymphoblastic leukemia
- macrophage
- integrin signaling
- VCAM-1
- Inhibitor
- inhibitor
- inhibit