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Cat. No.: HY-P3259

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AY254

AY254 is an analogue of AY77 (HY-138951). AY254 is ERK-biased PAR2 agonist with an EC₅₀ of 2 nM. AY254 relieves cytokine-induced caspase 3/8 activation. AY254 also promotes scratch-wound healing and induced IL-8 secretion via PAR2-ERK1/2 signaling

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2093408-03-6
화학식: C₃₀H₄₉N₉O₆
분자량:631.77

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AY254 Chemical Structure

CAS No.: 2093408-03-6

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가격

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수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

PAR2

2 nM (EC₅₀)

All Protease Activated Receptor (PAR) Isoforms :

Chemical Information

CAS No. 2093408-03-6
분자량 631.77
화학식 C₃₀H₄₉N₉O₆
Sequence

{5-Isoxazolylcarbonyl-Cha}-{Chg}-Ala-Arg-NH2
Sequence Shortening

{5-Isoxazolylcarbonyl-Cha}-{Chg}-AR-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

AY254

Vorapaxar

AZ3451

Parmodulin 2

BMS-986120

PAR-2 (1-6) (human)

GB-88

I-191

TRAP-6 amide

FLLRN

iso-TRAP-6

Protease-Activated Receptor-1, PAR-1 Agonist

Vorapaxar (Standard)

All Protease Activated Receptor (PAR) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AY254

Vorapaxar

AZ3451

Parmodulin 2

BMS-986120

PAR-2 (1-6) (human)

GB-88

I-191

TRAP-6 amide

FLLRN

iso-TRAP-6

Protease-Activated Receptor-1, PAR-1 Agonist

Vorapaxar (Standard)

All Protease Activated Receptor (PAR) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AY254 Related Classifications

HY-P3259 Related Classifications