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Cat. No.: HY-138951

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AY77

Name: AY77
Brand: MedChemExpress
SKU: HY-138951
Price: 792.00 USD
Availability: InStock
Rating: 5 (1 reviews)

AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC₅₀ of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca²⁺ release.

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CAS No.: 1835734-92-3
화학식: C₂₁H₃₂N₄O₄
분자량:404.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AY77 Chemical Structure

CAS No.: 1835734-92-3

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가격

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

IC₅₀ & Target

PAR2

All Protease Activated Receptor (PAR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	2 μM Compound: 2; AY77	Agonist activity at PK1-tagged PAR2 (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin recruitment incubated for 90 mins by Pathhunter chemiluminescent assay Agonist activity at PK1-tagged PAR2 (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin recruitment incubated for 90 mins by Pathhunter chemiluminescent assay	[PMID: 32551018]
HEK-293T	EC₅₀	0.17 μM Compound: 2; AY77	Agonist activity at human PAR2 expressed in HEK293T cells assessed as induction of Galphaq-stimulated IP1 formation incubated for 2 hrs by FRET assay Agonist activity at human PAR2 expressed in HEK293T cells assessed as induction of Galphaq-stimulated IP1 formation incubated for 2 hrs by FRET assay	[PMID: 32551018]

Chemical Information

CAS No. 1835734-92-3
분자량 404.50
화학식 C₂₁H₃₂N₄O₄
Sequence

{5-Isoxazolylcarbonyl-Cha}-{Chg}-NH2
Sequence Shortening

{5-Isoxazolylcarbonyl-Cha}-{Chg}-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Klösel I, et al. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323. [Content Brief]

[2]. Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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AY77

Vorapaxar

Vorapaxar (Standard)

Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Atopaxar

Vorapaxar sulfate

ENMD-1068 hydrochloride

I-287

Vorapaxar sulfate (Standard)

Atopaxar hydrobromide

All Protease Activated Receptor (PAR) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

AY77

Vorapaxar

Vorapaxar (Standard)

Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Atopaxar

Vorapaxar sulfate

ENMD-1068 hydrochloride

I-287

Vorapaxar sulfate (Standard)

Atopaxar hydrobromide

All Protease Activated Receptor (PAR) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AY77 Related Classifications

HY-138951 Related Classifications

Bioz