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Cat. No.: HY-168967

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BAY-277

BAY-277, a chemical probe, is a METAP2 degrader, with IC₅₀ values of 5.8 nM and 5.9 nM for hMETAP2 and mMETAP2, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₄₄H₅₂N₈O₅
분자량:772.93

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

BAY-277 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

BAY-277, a chemical probe, is a METAP2 degrader, with IC₅₀ values of 5.8 nM and 5.9 nM for hMETAP2 and mMETAP2, respectively^[1].

All MetAP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	DC₅₀	8.93 nM Compound: EUB0003014	Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE)) Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE))	10.6019/CHEMBL5463725
HUVEC	DC₅₀	0.2 nM Compound: EUB0003014	Degradation in HUVEC cells (WB) (Western Blot (WB)) Degradation in HUVEC cells (WB) (Western Blot (WB))	10.6019/CHEMBL5463725
HUVEC	IC₅₀	12 nM Compound: EUB0003014	2D HUVEC cells proliferation assay 2D HUVEC cells proliferation assay	10.6019/CHEMBL5463725

In Vitro

BAY-277 exhibits DC₅₀ of 8.93 nM for the degradation in HT1080 cells (CE), DC₅₀ of 0.2 nM for the degradation in HUVEC cells (WB) and IC₅₀ of 12 nM in the 2D HUVEC cells proliferation assay.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 772.93
화학식 C₄₄H₅₂N₈O₅
SMILES

O=C(N1CCC(C2=CC=C3C(CN(C4C(NC(CC4)=O)=O)C3=O)=C2)CC1)CCCCCN(CC5)CCC5C6=CC=C(C=C6)OC7=NN8C(C9=C7CCCC9)=NN=C8
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Overview for BAY-277 a degrader of METAP2.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

BAY-277

All MetAP Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BAY-277 Related Classifications

HY-168967 Related Classifications