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Cat. No.: HY-107036

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BMS-394136

Name: BMS-394136
Brand: MedChemExpress
SKU: HY-107036
Price: 503.00 USD
Availability: InStock
Rating: 5 (1 reviews)

BMS-394136 (compound 1) is a potent inhibitor of Kv 1.5, with an IC₅₀ of 0.05 μM. BMS-394136 is a selective IKur inhibitor. BMS-394136 dose-dependently prolongs atrial effective refractory period (AERP) and action potential duration (APD) without effecting ventricular effective refractory period (VERP). BMS-394136 can be used for acute atrial ischemia research.

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CAS No.: 343246-73-1
화학식: C₂₄H₂₁Cl₂FN₄O
분자량:471.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

BMS-394136 Chemical Structure

CAS No.: 343246-73-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
L929	IC₅₀	0.05 μM Compound: 7d	Inhibition of human Kv1.5 channel expressed in mouse L929 cells Inhibition of human Kv1.5 channel expressed in mouse L929 cells	[PMID: 20097068]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 343246-73-1
분자량 471.35
화학식 C₂₄H₂₁Cl₂FN₄O
SMILES

O=C(C1=C(NC2=CC=NN2[C@@H]1C3=CC(Cl)=C(C=C3)Cl)C)N4[C@@H](CCC4)C5=CC=C(C=C5)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gunaga P, et al. Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide. J Med Chem. 2017 May 11;60(9):3795-3803. [Content Brief]

[2]. Dezhi Xing, et al. Abstract 12964: Acute Atrial Ischemia Increases the Activity of BMS-394136, a Selective IKur Inhibitor, on Atrial Refractoriness and APD. Originally published 23 Mar 2018. Circulation. 2010;122:A12964.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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