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Cat. No.: HY-13498

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BRD-8899

Name: BRD-8899
Brand: MedChemExpress
SKU: HY-13498
Price: 630.00 USD
Availability: InStock
Rating: 5 (1 reviews)

BRD-8899 is a STK33 inhibitor, with an IC₅₀ of 11 nM.

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CAS No.: 1404437-50-8
화학식: C₁₇H₂₂N₄O₃S
분자량:362.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

BRD-8899 Chemical Structure

CAS No.: 1404437-50-8

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

BRD-8899 is a STK33 inhibitor, with an IC₅₀ of 11 nM^[1].

IC₅₀ & Target

IC50: 11 nM (STK33)^[1].

In Vitro

BRD8899 (1, 10, 20 μM, 24 h) results in decreased phosphorylation of the MST4 substrate ezrin in NOMO-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Western Blot Analysis^[1]

View Protocol

Cell Line:

NOMO-1 cells.
Concentration:

1, 10, 20 μM.
Incubation Time:

24 h.
Result:

Decreased p-Ezrin levels.

Chemical Information

CAS No. 1404437-50-8
분자량 362.45
화학식 C₁₇H₂₂N₄O₃S
SMILES

CC1=C2C(C=CC=C2S(N[C@@H]3C[C@@H](CNC(C)=O)NC3)(=O)=O)=CN=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tuoping Luo, et al. STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2860-5. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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