Bromoriluzole
Bromoriluzole is a derivative of Riluzole (HY-B0211). Bromoriluzole inhibits Ca2+ -dependent Calmodulin-SK4 channel interaction. Bromoriluzole is used for the research of neurodegenerative diseases.
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- CAS No.: 144631-82-3
- 화학식: C8H4BrF3N2OS
- 분자량:313.09
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Bromoriluzole (Compound 1) (100 μM) inhibits Ca2+-dependent interactions between calmodulin and the SK4 channel S4S5 linker (measured via FRET biosensor) with a total amplitude inhibition of 24.1% and Phase II amplitude inhibition of 31.2% at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 144631-82-3
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Appearance solid
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분자량 313.09
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화학식 C8H4BrF3N2OS
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Color Light yellow to yellow
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SMILES
FC(F)(F)OC=1C=C(Br)C=2N=C(SC2C1)N
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Baltasar-Marchueta M, et al. Identification of Riluzole derivatives as novel calmodulin inhibitors with neuroprotective activity by a joint synthesis, biosensor, and computational guided strategy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May;174:116602. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bromoriluzole Related Classifications
HY-W166106 Related Classifications
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