Butabindide
Based on 2 publication(s) in Google Scholar
Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation.
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- CAS No.: 175553-48-7
- 화학식: C17H25N3O2
- 분자량:303.40
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Butabindide
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Biological Activity
IC50: 7 nM (TPP II) and 10 μM (TPP I)[1]
Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) inhibits TPP II activity of cerebral membranes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (25-30 g)
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Dosage:10 mg/kg
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Administration:Intravenous injection; for 20 minutes
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Result:Reduces food intake and elicits other behavioral concomitants of satiation.
Chemical Information
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CAS No. 175553-48-7
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분자량 303.40
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화학식 C17H25N3O2
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SMILES
CC[C@H](N)C(N1C2=CC=CC=C2C[C@H]1C(NCCCC)=O)=O
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Synonyms
UCL-1397
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Biol Chem
Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding. [Abstract]2018 Dec 7;293(49):18864-18878. PMID: 30291141 -
순도&문서
References
[1]. Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48(23):7333-42. [Content Brief]
[2]. Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380(6573):403-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Butabindide Related Classifications
HY-150070 Related Classifications
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