NR162
Based on 1 Customer Validation
NR162 is a selective CASK (Ca2+/calmodulin-dependent Ser/Thr kinase) inhibitor with an IC50 of 80 nM and a Kd of 22 nM. NR162 shows about 50-fold selectivity for CASK than TYRO3. NR162 targets the unique GFG motif of CASK and has excellent shape complementarity to the CASK ATP binding pocket. NR162 can be used for the research of neurological diseases.
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- Purity: 99.7%
- CAS No.: 2755241-73-5
- 화학식: C24H30Br2N6O3
- 분자량:610.34
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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CASK 80 nM (IC50) |
CASK 22 nM (Kd) |
NR162 (1 μM) shows excellent selectivity for CASK in kinome-wide profiling. NR162 weakly inhibits TYRO3 and CSNK1E, with IC50 values of 3.79 μM and 10.9 μM, respectively, and shows no inhibitory effect on MERTK, AXL, and ABL1[1].
NR162 (1 μM; 6 days) does not impair differentiation or affect β3-tubulin abundance in P19 cells[1].
NR162 (2 μM) causes cell death in differentiating P19 cells[1].
NR162 (10 μM) has no effect on growth or toxicity in NCI60 cancer cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2755241-73-5
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Appearance Solid
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분자량 610.34
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화학식 C24H30Br2N6O3
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Color White to off-white
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SMILES
O=C(C1=CN=C(N=C1NC2CCCC2)NCC3=CC(Br)=C(C=C3Br)C)NCCCN4CCOC4=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 12.21 mg/mL (20.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6384 mL | 8.1922 mL | 16.3843 mL | 40.9608 mL |
| 5 mM | 0.3277 mL | 1.6384 mL | 3.2769 mL | 8.1922 mL | |
| 10 mM | 0.1638 mL | 0.8192 mL | 1.6384 mL | 4.0961 mL | |
| 15 mM | 0.1092 mL | 0.5461 mL | 1.0923 mL | 2.7307 mL | |
| 20 mM | 0.0819 mL | 0.4096 mL | 0.8192 mL | 2.0480 mL |
NR162 Related Classifications
HY-115719 Related Classifications
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