CB1/2 agonist 2
CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand, with Ki values of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a full CB1 agonist and CB2 competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity.
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- CAS No.: 2772379-97-0
- 화학식: C26H43NO3
- 분자량:417.62
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
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hCB2-R 1.2 nM (Ki) |
hCB1-R 3.5 nM (Ki) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
397.9 nM
Compound: 23
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Agonist activity at human CB2 receptor expressed in CHO cell membrane assessed as inhibition of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scintillation counting assay
Agonist activity at human CB2 receptor expressed in CHO cell membrane assessed as inhibition of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scintillation counting assay
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[PMID: 32340793] |
| CHO | EC50 |
6.21 nM
Compound: 23
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Agonist activity at human CB1 receptor expressed in CHO cell membrane assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scintillation counting assay
Agonist activity at human CB1 receptor expressed in CHO cell membrane assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scintillation counting assay
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[PMID: 32340793] |
In Vitro
CB1/2 agonist 2 (compound 23) (1 µM, 24-72 h) exhibits a very low cytotoxic potential in Hep-G2 cells[1].
CB1/2 agonist 2 (0-10 µM) shows a slight but significant inhibition of [35S]GTPγS binding to hCB2-CHO cell membranes, with a mean EC50 of 397.90 nM and a mean Emax value of -17.81%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human hepatoblastoma (Hep-G2) cells
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Concentration:1 µM
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Incubation Time:24, 48 or 72 h
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Result:Exhibited a very low cytotoxic potential, as Hep-G2 cell viability was comparable to controls after 24-72 h of treatment.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD-1 outbred mice (40-45 g)[1]
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Dosage:0, 1, 3, and 6 mg/kg
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Administration:IP, once, 10 min before the formalin or saline injection
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Result:Significantly reduced the late phase of formalin-induced nocifensive behaviour at the highest dose (6 mg/kg, i.p.), whereas no effect was produced by doses of 1 and 3 mg/kg.
Chemical Information
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CAS No. 2772379-97-0
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분자량 417.62
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화학식 C26H43NO3
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SMILES
O=C(NC1CC1)CCCCCCCCCCOC2=CC(CCCCC)=CC(OC)=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CB1/2 agonist 2 Related Classifications
HY-150028 Related Classifications
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