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Cat. No.: HY-189746

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CBD-TSC1

CBD-TSC1 is a reversible mixed-type inhibitor of human and mushroom tyrosinase, with an IC₅₀ of 27.72 μM against mushroom tyrosinase. CBD-TSC1 interacts with both the free enzyme and the enzyme-substrate complex. CBD-TSC1 reduces intracellular reactive oxygen species (ROS) levels under oxidative stress as well as melanin content in zebrafish larvae.

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화학식: C₂₃H₃₃N₃O₂S
분자량:415.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CBD-TSC1 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

mushroom Tyrosinase

27.72 μM (IC₅₀)

In Vitro

Anti-cancerOxidative StressOthers

Anti-cancer

CBD-TSC1 (5-20 μM; 8-24 h) maintains the viability of G361 melanoma cells and HaCaT keratinocytes above 70%^[1].

Oxidative Stress

Anti-cancer

CBD-TSC1 (0.625-2.5 μM; 24 h pre-incubation) reduces H₂O₂-induced intracellular ROS in HaCaT and G361 cells, with a significant reduction at 2.5 μM^[1].

Others

CBD-TSC1 (0-75 μM) inhibits human tyrosinase diphenolase activity in G361 melanoma cell lysates with an IC₅₀ of 34.47 μM and acts as a mixed-type inhibitor with a K_i of 26.96 μM^[1].
CBD-TSC1 inhibits mushroom tyrosinase diphenolase with an IC₅₀ of 27.72 μM, and as a reversible mixed-type inhibitor, it prolongs the lag phase of monophenolase by 5.5 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

G361 human melanoma cells and HaCaT human keratinocytes
Concentration:

5 μM; 10 μM; 15 μM; 20 μM
Incubation Time:

8, 12, 24 h
Result:

At short-term exposure (up to 24 h), CBD-TSC1 was well tolerated in both cell lines, with viability remaining above 70% across all tested concentrations.
These findings indicate that CBD-TSC1 exhibited low acute cytotoxicity under the tested conditions and showed a comparable or slightly improved tolerability profile relative to CBD during the initial 12 h of exposure.

Related Protocols :

ROS/oxidative-stress fluorescent staining

Chemical Information

분자량 415.59
화학식 C₂₃H₃₃N₃O₂S
SMILES

CC1=C[C@@H](C2=C(O)C=C(CCCCC)C(/C=N/NC(N)=S)=C2O)[C@H](C(C)=C)CC1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Shabat-Simon M, et al. Cannabidiol-thiosemicarbazone exhibits dual tyrosinase inhibition and antioxidant activity in human skin-derived cells. Bioorganic & medicinal chemistry letters. 2026 Oct;139:130707.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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