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Cat. No.: HY-P12276

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CDR3a23

CDR3a23 is a CD38 inhibitor and apoptosis inducer (human K_d = 630 nM) that binds to CD38 epitope 2 to block its function, induces apoptosis and G1 phase cell cycle arrest, thereby inhibiting cell growth. CDR3a23 can be used in research on hematological malignancies.

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화학식: C₁₃₆H₁₇₉N₃₁O₄₂S
분자량:2952.12

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDR3a23 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

CD38

630 nM (Kd)

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC50	540 nM	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay. Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay.	40652724
HL-60	IC50	390 nM	Antiproliferative activity against human HL-60 cells in combination with 1 μM ATRA assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay. Antiproliferative activity against human HL-60 cells in combination with 1 μM ATRA assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay.	40652724

In Vitro

Innate ImmunityAnti-cancerApoptosisCell Cycle RegulationOthers

Innate Immunity

Anti-cancer

CDR3a23 (L-pep) (40-800 nM; 4 h) specifically binds to CD38 on the surface of HL-60 cells, with a binding affinity higher than that of cyclic C-pep^[1].
CDR3a23 (L-pep) (100-2000 nM; 4 h) binds to CD38 on HL-60 cells with a K_d of 630 nM^[1].

Anti-cancer

CDR3a23 (L-pep) (800 nM; 3 days) exhibits a time-dependent antiproliferative effect on HL-60 cells, but not on SH-SY5Y cells^[1].
CDR3a23 (L-pep) (100-1000 nM; 48 h) inhibits HL-60 cell proliferation with an IC₅₀ of 540 nM, which decreases to 390 nM when combined with 1 μM Retinoic acid (ATRA) (HY-14649), while showing no effect on SH-SY5Y cells^[1].

Apoptosis

CDR3a23 (L-pep) (540 nM; 48 h) induces 47.5% total apoptosis in HL-60 cells at its IC₅₀ concentration, and this proportion increases to 72.5% when combined with 1 μM ATRA^[1].

Cell Cycle Regulation

CDR3a23 (L-pep) (540 nM; 48 h) induces G1 phase arrest in 52.21% of HL-60 cells, and this proportion increases to 65.9% when combined with 1 μM ATRA^[1].

Others

CDR3a23 peptide (100 ns) stably binds to the active site of human CD38 with a binding energy of -10.2 kcal/mol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HL-60; SH-SY5Y
Concentration:

800 nM (L-pep)
Incubation Time:

3 days
Result:

Exhibited a substantial and time-dependent anti-proliferative impact on HL-60 cells after 24 h.
Greatly suppressed the proliferation of HL-60 cells in combination with 1 μM ATRA.
Did not affect the population of SH-SY5Y cells even after 72 h.

Cell Viability Assay^[1]

Cell Line:

HL-60; SH-SY5Y
Concentration:

100, 300, 700, 1000 nM (L-pep)
Incubation Time:

48 h
Result:

Inhibited HL-60 cell proliferation with an IC₅₀ of 540 nM.
Decreased IC₅₀ to 390 nM when combined with 1 μM ATRA.
Had no effect on SH-SY5Y cells.

Apoptosis Analysis^[1]

Cell Line:

HL-60
Concentration:

540 nM (L-pep)
Incubation Time:

48 h
Result:

Induced total apoptosis in 47.5% of HL-60 cells.
Increased total apoptosis to 72.5% when combined with 1 μM ATRA.

Cell Cycle Analysis^[1]

Cell Line:

HL-60
Concentration:

540 nM (L-pep)
Incubation Time:

48 h
Result:

Induced G1 phase arrest in 52.21% of HL-60 cells.
Increased G1 phase arrest to 65.9% when combined with 1 μM ATRA.

Related Protocols :

Chemical Information

분자량 2952.12
화학식 C₁₃₆H₁₇₉N₃₁O₄₂S
SMILES

O=C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CC8=CNC9=CC=CC=C89)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Sequence

Ala-Ala-Gln-Tyr-Gln-Asp-Arg-Tyr-Tyr-Asp-Glu-Phe-Thr-Trp-Lys-Glu-Lys-Asp-Met-Asp-Tyr-Trp
Sequence Shortening

AAQYQDRYYDEFTWKEKDMDYW
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Nabi-Afjadi M, et al. Design, synthesis, and evaluation of the effect of potential peptides against CD38: An in silico and in vitro study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2025 Aug;189:118347.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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