CGP36216
CGP36216 is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders.
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- CAS No.: 123691-29-2
- 화학식: C5H14NO2P
- 분자량:151.14
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
GABAB receptor[1]
CGP36216 is ineffective at GABA postsynaptic receptors, it is appreciably more active at presynaptic receptors[2].
CGP36216 (100 µM) could increase the frequency of spontaneous firing in VTA-DA neurons[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[3].
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Dosage:20 μg/Rat.
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Administration:Intra-VTA injection (ventral tegmental area).
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Result:Abolishes CPP induced by intra-VTA injection of morphine.
Chemical Information
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CAS No. 123691-29-2
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분자량 151.14
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화학식 C5H14NO2P
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SMILES
O=P(CC)(CCCN)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[2]. J Ong, et al. CGP 36216 is a selective antagonist at GABA(B) presynaptic receptors in rat brain. Eur J Pharmacol. 2001 Mar;415(2-3):191-5. [Content Brief]
[3]. Ming Chen, et al. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. Elife. 2015 Jul 24:4:e09275. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGP36216 Related Classifications
HY-103518 Related Classifications
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