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Cat. No.: HY-18228

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CP-352664

CP-352664 is a JAK inhibitor. CP-352664 has a inhibitoinhibits JAK3 with an EC₅₀ value of 210 nM. CP-352664 is promising for research of organ transplant rejection and autoimmune disorders such as rheumatoid arthritis.

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CAS No.: 1097883-05-0
화학식: C₁₈H₁₈N₄
분자량:290.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

CP-352664 Chemical Structure

CAS No.: 1097883-05-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
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Classifications
Bioz

Biological Activity

제품 설명

All JAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	IC₅₀	10 μM Compound: CP-352664	Inhibition of fetal calf serum-induced proliferation of human foreskin fibroblast assessed as [3H]thymidine incorporation after 4 days by scintillation counting Inhibition of fetal calf serum-induced proliferation of human foreskin fibroblast assessed as [3H]thymidine incorporation after 4 days by scintillation counting	[PMID: 14593182]
Sf9	IC₅₀	210 nM Compound: 2a	Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA	[PMID: 21105711]
Sf9	IC₅₀	>10000 nM Compound: 2a	Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISA Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISA	[PMID: 21105711]
T-cell	IC₅₀	3694 nM Compound: CP-352664	Inhibition of IL2-induced proliferation of human T cells assessed as [3H]thymidine incorporation after 72 hrs by scintillation counting Inhibition of IL2-induced proliferation of human T cells assessed as [3H]thymidine incorporation after 72 hrs by scintillation counting	[PMID: 14593182]
T-cell	IC₅₀	3200 nM Compound: 2a	Inhibition of human IL2-dependent T cell blast proliferation assessed as reduction in [3H]thymidine incorporation after 72 hrs post dose IL2 blast assay Inhibition of human IL2-dependent T cell blast proliferation assessed as reduction in [3H]thymidine incorporation after 72 hrs post dose IL2 blast assay	[PMID: 21105711]

Chemical Information

CAS No. 1097883-05-0
분자량 290.36
화학식 C₁₈H₁₈N₄
SMILES

C1(N2C3=C(C4C2CCCC4)C=CC=C3)=C5C=CNC5=NC=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Flanagan ME, et al. Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. J Med Chem. 2010 Dec 23;53(24):8468-84. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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CP-352664

All JAK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CP-352664 Related Classifications

HY-18228 Related Classifications