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Cat. No.: HY-P99834

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Biologically Validated

Crefmirlimab

Name: Crefmirlimab
Brand: MedChemExpress
SKU: HY-P99834
Price: 380.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: IAB22M2C; ImaginAb)

고객리뷰

Based on 1 Customer Validation

Crefmirlimab (IAB22M2C; ImaginAb) is a humanized CD8-specific single-domain antibody. Conjugation of Crefmirlimab with radioisotopes (e.g., ⁸⁹Zr) enables tumor immune infiltration assessment, autoimmune disease detection, and immunotherapy response monitoring. Crefmirlimab is applicable for cancer research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 97.616%
CAS No.: 2611099-93-3
분자량:79.946 kDa

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Crefmirlimab Chemical Structure

CAS No.: 2611099-93-3

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- 신청
- Verified Bioactivity
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Isotype

(scFv-kappa-heavy)-h-CH3

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CD8A

In Vivo

⁸⁹Zr-Df-Crefmirlimab (48-81 μCi; i.v.) enables non-invasive, dose- and time-dependent quantification of intratumoral CD8⁺ T cell recruitment in a human colorectal cancer adoptive transfer mouse model, with moderate correlation to immunohistochemical CD8⁺ T cell density (R² up to 0.46)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD-SCID IL-2Rγ null (NSG) (female)^[1]
Dosage:

48-81 μCi (delivering ~50 μg)
Administration:

i.v.
Result:

Showed substantial uptake in CD8⁺ T cell-rich tissues (spleen and tumors) with minimal accumulation in background tissues (muscle, whole blood).
Detected dose-dependent increases in tumor uptake on day 9 post-bispecific antibody treatment, with a mean SUV of up to 1.54 (SEM) in the highest-dose bispecific antibody group.
Confirmed dose- and time-dependent tumor uptake via ex vivo gamma counting, with a mean tumor uptake of 13.0%ID/g (SEM) in the highest-dose bispecific antibody group on day 9.
Showed moderate correlation between tumor radiotracer uptake (SUV or %ID/g) and CD8⁺ T cell density via immunohistochemistry (R² = 0.46 and R² = 0.45, respectively) on day 9.
Achieved tumor-to-blood ratios >8 and tumor-to-muscle ratios >27 for the highest bispecific antibody dose on day 9.

Gene ID

925 [NCBI]

Accession

P01732

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

(scFv-kappa-heavy)-h-CH3

신청

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized CD8 alpha Protein, Human (HEK293, His, HY-P71662) can bind Crefmirlimab. The EC₅₀ for this effect is 532.3 ng/mL.

Chemical Information

CAS No. 2611099-93-3
Appearance Liquid
분자량 79.946 kDa
Color Colorless to light yellow
SMILES

[Crefmirlimab]
Synonyms

IAB22M2C; ImaginAb
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Maresca KP, et al. Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy. Mol Imaging Biol. 2021 Dec;23(6):941-951. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- 신청
- Biological Activity
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Crefmirlimab

Protein A Agarose

Bradford Protein Assay Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)