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Cat. No.: HY-W783351

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CS790AM

(Synonyms: Coppersensor 790 acetoxymethyl ester)

CS790AM (Coppersensor 790 acetoxymethyl ester) is a cell-permeable, Cu⁺-targeted near-infrared fluorescent probe (λ_abs=760 nm, λ_em=790 nm) applicable to live cells. CS790AM can cross lipophilic cell membranes, and is converted into negatively charged CS790 under the action of intracellular esterases to be retained, thus enabling highly sensitive, reversible "turn-on" detection of labile Cu⁺ pools in live cells and mice. CS790AM possesses excellent biocompatibility and selectivity, avoids interference from other metal ions, shows no obvious toxicity, and can be rapidly cleared. CS790AM allows long-term longitudinal monitoring of individual mice, visualizes copper levels in internal organs and isolated livers, and effectively evaluates abnormal copper accumulation in Wilson's disease models (Atp7b^-/-) as well as dynamic changes after chelator treatment. CS790AM can be used for research on Wilson's disease and related copper metabolic disorders.

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CAS No.: 1416808-87-1
화학식: C₅₆H₇₀BrN₃O₉S₃
분자량:1105.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CS790AM Chemical Structure

CAS No.: 1416808-87-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

CS790AM, a Cy7-based fluorescent probe, produces a 17-fold fluorescence turn-on response upon binding to Cu⁺ in cell-free conditions^[1].
CS790AM (2 μM; 15 min at 37 °C) reversibly detects fluctuations in labile copper levels in HEK 293T cells, with a significant increase in mean fluorescence intensity in copper-overloaded cells that is reversed by copper chelation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CS790AM (0.1 mM; i.p.; single dose) detects dynamic fluctuations in labile Cu⁺ levels in healthy SKH-1 mice, producing a ~60% fluorescence increase in copper-overloaded mice and reduced signal in copper-depleted mice, with reversible responses to chelation^[2].
CS790AM (0.1 mM; i.p.; single dose) detects aberrantly elevated labile Cu⁺ levels in Atp7b^-/^- Wilson disease model mice, producing significantly higher fluorescence signal than in wild-type mice at 30 minutes post-injection, with signal reducible by copper chelation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SKH-1 (hairless)^[2]
Dosage:

0.1 mM
Administration:

i.p.; single dose
Result:

Reversed the ~60% fluorescence increase when co-administered with ATN-224 (HY-16074).
Showed significantly lower fluorescence in mice pretreated with ATN-224 alone compared to mice treated with CS790AM alone.
Confirmed higher fluorescence in copper-pretreated mice via ex vivo liver imaging, with total photon flux values significantly elevated compared to vehicle-pretreated controls.
Showed sustained elevated fluorescence in copper-pretreated mice relative to controls for up to 9 hours post-injection, with signal fully attenuated by 72 hours.

Animal Model:

C57BL/6 (7-11 weeks old, female; Wilson disease model via Atp7b gene inactivation); wild-type (7-11 weeks old, female)^[2]
Dosage:

0.1 mM
Administration:

i.p.; single dose
Result:

Exhibited significantly higher in vivo fluorescence signal in Atp7b^-/- mice than wild-type mice at 30 minutes post-injection.
Showed reduced fluorescence in ATN-224-pretreated Atp7b^-/- mouse livers compared to vehicle-pretreated controls via ex vivo imaging, correlating with decreased copper levels in serum.

Chemical Information

CAS No. 1416808-87-1
분자량 1105.27
화학식 C₅₆H₇₀BrN₃O₉S₃
SMILES

O=C(CC[N+]1=C(C(C)(C2=CC=CC=C21)C)/C=C/C(CCC/C3=C\C=C4N(C5=CC=CC=C5C\4(C)C)CCC(OCOC(C)=O)=O)=C3OC6=CC(SCCCSC)=C(C=C6)NCCCSC)OCOC(C)=O.[Br-]
Synonyms

Coppersensor 790 acetoxymethyl ester
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ackerman C M, et al. Analytical methods for imaging metals in biology: from transition metal metabolism to transition metal signaling[J]. Analytical chemistry, 2017, 89(1): 22-41.

[2]. Hirayama T, et al. Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model. Proc Natl Acad Sci U S A. 2012;109(7):2228-2233. [Content Brief]

[3]. Cotruvo JA Jr, et al. Synthetic fluorescent probes for studying copper in biological systems. Chem Soc Rev. 2015;44(13):4400-4414. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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