CTP
Based on 2 publication(s) in Google Scholar
CTP (cardiac targeting peptide) can transduce cardiomyocytes in vitro. CTP leads to efficient and specific transduction of heart tissue in mice model. CTP can be reversibly linked (e.g. via enolases, thiol groups) to cargo (e.g. miRNAs) for delivery specifically to cardiomyocytes over all other organs.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.54%
- CAS No.: 1052692-86-0
- 화학식: C64H93N19O19
- 분자량:1432.54
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보관:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CTP
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Biological Activity
CTP (50-200 μM, 30 min) leads to significant internalization in H9C2 cells when coupled with 6-CF[1].
CTP (50-400 μM, 30 min) is able to deliver the peptide NBD into H9C2 cells which inhibits the TNF-α (HY-P1860) (10 ng/mL) induced increase in NF-κB transcriptional activity[1].
CTP (5 μg/mL, 24-144 h) delivers miRNA106a which then reverses PE/Ang2-induced hypertrophic responses in hypertrophic human cardiomyocytes (HCMs)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CTP (10 mg/kg, i.v. retro-orbitally, single dose) specifically transduces cardiac tissue in BALB/c mice when coupled with biotin-SA488 in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice[1]
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Dosage:10 mg/kg
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Administration:Intravenous injection (i.v.) retro-orbitally, single dose
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Result:Retained in the heart 3 hour post-injection when combined with fluospheres.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1052692-86-0
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Appearance Solid
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분자량 1432.54
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화학식 C64H93N19O19
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Color White to off-white
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Synonyms
Cardiac targeting peptide
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Sequence
Ala-Pro-Trp-His-Leu-Ser-Ser-Gln-Tyr-Ser-Arg-Thr
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Sequence Shortening
APWHLSSQYSRT
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Acta Pharm Sin B
Super-resolution imaging for in situ monitoring sub-cellular micro-dynamics of small molecule drug. [Abstract]2024 Apr;14(4):1864-1877. PMID: 38572114 -
Nanomedicine
Precise atorvastatin delivery by cardiac homing peptide functionalized nanoliposomes for myocardial damage repair after myocardial infarction. [Abstract]2026 Mar;21(6):789-801. PMID: 41660754
용액&용해도
H2O : 100 mg/mL (69.81 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zahid M, et al. Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice. PLoS One. 2010 Aug 17;5(8):e12252. [Content Brief]
[2]. Gallicano, G. I., et al., (2022). Reversing Cardiac Hypertrophy at the Source Using a Cardiac Targeting Peptide Linked to miRNA106a: Targeting Genes That Cause Cardiac Hypertrophy. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 0.6981 mL | 3.4903 mL | 6.9806 mL | 17.4515 mL |
| 5 mM | 0.1396 mL | 0.6981 mL | 1.3961 mL | 3.4903 mL | |
| 10 mM | 0.0698 mL | 0.3490 mL | 0.6981 mL | 1.7452 mL | |
| 15 mM | 0.0465 mL | 0.2327 mL | 0.4654 mL | 1.1634 mL | |
| 20 mM | 0.0349 mL | 0.1745 mL | 0.3490 mL | 0.8726 mL | |
| 25 mM | 0.0279 mL | 0.1396 mL | 0.2792 mL | 0.6981 mL | |
| 30 mM | 0.0233 mL | 0.1163 mL | 0.2327 mL | 0.5817 mL | |
| 40 mM | 0.0175 mL | 0.0873 mL | 0.1745 mL | 0.4363 mL | |
| 50 mM | 0.0140 mL | 0.0698 mL | 0.1396 mL | 0.3490 mL | |
| 60 mM | 0.0116 mL | 0.0582 mL | 0.1163 mL | 0.2909 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
CTP Related Classifications
HY-P4094 Related Classifications
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