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Cat. No.: HY-185107

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CTR/AMYR modulator-2

CTR/AMYR modulator-2 is a dual agonist of human amylin receptor 3 (AMY3R) and calcitonin receptor (CTR). CTR/AMYR modulator-2 activates AMY3R and CTR, stimulating Rel EC₅₀ of cAMP production in UMUC3 cells by 4 nM and 1 nM, respectively. CTR/AMYR modulator-2 may be used in research on type 2 diabetes and obesity.

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CAS No.: 3108095-52-6
화학식: C₃₃H₃₅ClF₂N₈O₃
분자량:665.13

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CTR/AMYR modulator-2 Chemical Structure

CAS No.: 3108095-52-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

AMY3R

4 nM (EC₅₀)

CTR

1 nM (EC₅₀)

In Vitro

CTR/AMYR modulator‑2 (Example 107) acts as an agonist at the human amylin receptor (AMY3R) in UMUC3 cells, with a Rel EC₅₀ of 4 nM and an Emax of 99% as determined in a 20‑point concentration‑response assay following 30 min of incubation^[1].
CTR/AMYR modulator‑2 acts as an agonist at the human calcitonin receptor (CTR) in UMUC3 cells, with a Rel EC₅₀ of 1 nM and an Emax of 88% under the same 20‑point assay conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3108095-52-6
Appearance Powder
분자량 665.13
화학식 C₃₃H₃₅ClF₂N₈O₃
SMILES

O=C(C1=C(CC(C)C)N=C2C(C=NN2C3CCN(C4CC(F)(C4)F)CC3)=C1C5=CC(OCC(N6CC7=NC=C(C=N7)Cl)=O)=C6C=C5)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Renato A. BAUER, et al. 4-phenyl-1h-pyrazolo[3,4-b]pyridine-5-carboxamide derivatives as amylin and/or calcitonin receptor agonists for the treatment of type 2 diabetes, obesity or overweight. WO2025240893A1. 2025.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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