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Cat. No.: HY-181829

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Ctx-L3

Ctx-L3 is a selective EGFR PTAC (PSMA-targeted chimera) degrader (DC₅₀: 4.3 pM in LNCaP cells) and LYTAC. Ctx-L3 recruits prostate-specific membrane antigen (PSMA) and mediates lysosomal degradation of EGFR in PSMA-positive prostate cancer cells. Ctx-L3 exhibits degrading activity against EGFR in prostate cancer cells. Ctx-L3 is applicable to related research on prostate cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₇₂H₁₁₄N₁₀O₂₇
분자량:1551.73

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ctx-L3 Chemical Structure

사이즈

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All EGFR Isoforms :

In Vitro

Ctx-L3 (0.01-100 nM; 24 h) potently and selectively induces lysosomal degradation of EGFR in PSMA-positive prostate cancer cell lines, with a DC₅₀ of 4.3 pM in LNCaP cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 1551.73
화학식 C₇₂H₁₁₄N₁₀O₂₇
SMILES

O=C(CCC(NCCOCCOCCOCC(NCCCCCC(NCCCC[C@@H](C(O)=O)NC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)N(C1=C2C=CC=C1)CC(C=CC=C3)=C3C4=C2N=NN4CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(N)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Cai D, et al. Development of Prostate-Specific Lysosome-Targeting Degraders. J Am Chem Soc. 2026;148(7):7171-7180. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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