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Cat. No.: HY-182247

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D-473

D-473 is an orally active, blood-brain barrier-penetrant reuptake inhibitor with a preference for serotonin. D-473 inhibits the serotonin transporter (SERT), dopamine transporter (DAT), and norepinephrine transporter (NET), significantly elevating the extracellular levels of these three neurotransmitters in rat brain regions. D-473 exhibits clear antidepressant-like activity without inducing motor activation. D-473 is widely used in research related to major depressive disorder.

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CAS No.: 1632000-05-5
화학식: C₂₆H₂₇F₂NO₃
분자량:439.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

D-473 Chemical Structure

CAS No.: 1632000-05-5

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

D-473 (at least five triplicate concentrations spaced evenly around the IC₅₀ value) potently inhibits monoamine uptake in HEK 293 cells expressing cloned human hDAT, hSERT, and hNET, with highest potency for hSERT (K_i = 9.18 ± 1.69 nM), followed by hNET (K_i = 39.7 ± 7.6 nM) and hDAT (K_i = 70.4 ± 16.7 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rat

D-473 (5-50 mg/kg; p.o.; single dose; 1 hour prior to 5-minute swim test) produces dose-dependent, statistically significant reductions in immobility time in the rat forced swim test^[1].
D-473 (25 mg/kg; p.o.; single dose) does not significantly alter locomotor activity in rats^[1].
D-473 (10 mg/kg; i.p.; single dose) significantly elevates extracellular dopamine, serotonin, and norepinephrine in the rat mPFC and DLS, while reducing levels of dopamine metabolites in these regions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rat with major depressive disorder (male, 200-225 g)^[1]
Dosage:

5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg
Administration:

p.o.; single dose; 1 hour prior to 5-minute swim test
Result:

Produced no significant reduction in immobility time at 5 mg/kg.
Reduced immobility time significantly compared to vehicle at 10 mg/kg.
Reduced immobility time significantly compared to vehicle at 25 mg/kg.
Reduced immobility time significantly compared to vehicle at 50 mg/kg.

Chemical Information

CAS No. 1632000-05-5
분자량 439.49
화학식 C₂₆H₂₇F₂NO₃
SMILES

O[C@@H]([C@@H](CO1)NCC2=CC=C(C=C2)OC)C[C@H]1C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dutta AK, et al. Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters. PLoS One. 2014;9(11):e113420. Published 2014 Nov 26. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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D-473