D-65476
D-65476 is an inhibitor of type Ⅲ receptor tyrosine kinase (Flt3). In the absence of IL-3, D-65476 inhibits the proliferation of TEL-Flt3 transfected BA/F3 cells (IC50= 0.2 μM), which can be used in the study of Flt3-driven leukemia.
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- CAS No.: 249762-74-1
- 화학식: C21H18N2O3
- 분자량:346.38
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
1.1 μM
Compound: 52
|
Antitumor activity measured by the inhibition of platelet-derived growth factor receptor autophosphorylation in intact Swiss 3T3 cells
Antitumor activity measured by the inhibition of platelet-derived growth factor receptor autophosphorylation in intact Swiss 3T3 cells
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[PMID: 11855980] |
Chemical Information
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CAS No. 249762-74-1
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분자량 346.38
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화학식 C21H18N2O3
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SMILES
O=C(CCC)OC1=CC2=C(NC(C(C3=CC4=C(N3)C=CC=C4)=O)=C2)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D-65476 Related Classifications
HY-112378 Related Classifications
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