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Cat. No.: HY-121634

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DAP-81

DAP-81 is an inhibitory agent targeting Polo-like kinases (Plks), a class of evolutionarily conserved serine/threonine kinases. DAP-81 dose-dependently increases the number of monopolar spindles in treated cells. High-resolution live-cell microscopy revealed that Plk activity is required for the assembly and maintenance of bipolar mitotic spindles. Plk inhibition destabilizes centromeric microtubules while stabilizing other spindle microtubules, leading to the formation of monopolar spindles. Further testing of compounds based on "privileged scaffolds" such as the DAP scaffold may lead to the discovery of new cell division probes and anti-microtubule agents.

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CAS No.: 794466-17-4
화학식: C₂₅H₂₀N₆O₄
분자량:468.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DAP-81 Chemical Structure

CAS No.: 794466-17-4

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Polo-like Kinase (PLK) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BSC-1	EC₅₀	5 μM Compound: 1, DAP-81	Antimitotic activity against african green monkey BSC1 cells assessed as induction of monopolar spindles by immunofluorescence microscopy Antimitotic activity against african green monkey BSC1 cells assessed as induction of monopolar spindles by immunofluorescence microscopy	[PMID: 17028580]

Chemical Information

CAS No. 794466-17-4
분자량 468.46
화학식 C₂₅H₂₀N₆O₄
SMILES

CC(NC1=CC=C(C=C1)NC2=NC=C(C(NC3=CC=CC=C3C(C4=CC=CC=C4)=O)=N2)[N+]([O-])=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Probing cell-division phenotype space and Polo-like kinase function using small molecules

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
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DAP-81

All Polo-like Kinase (PLK) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DAP-81 Related Classifications

HY-121634 Related Classifications