DBCO-PEG12-NHS ester
Based on 1 Customer Validation
DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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- Purity: 98.68%
- CAS No.: 2093934-94-0
- 화학식: C50H71N3O18
- 분자량:1002.11
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보관:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
Alkyl/ether |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2093934-94-0
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Appearance Oil
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분자량 1002.11
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화학식 C50H71N3O18
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Color Colorless to light yellow
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SMILES
O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
DMSO : 100 mg/mL (99.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9979 mL | 4.9895 mL | 9.9789 mL | 24.9474 mL |
| 5 mM | 0.1996 mL | 0.9979 mL | 1.9958 mL | 4.9895 mL | |
| 10 mM | 0.0998 mL | 0.4989 mL | 0.9979 mL | 2.4947 mL | |
| 15 mM | 0.0665 mL | 0.3326 mL | 0.6653 mL | 1.6632 mL | |
| 20 mM | 0.0499 mL | 0.2495 mL | 0.4989 mL | 1.2474 mL | |
| 25 mM | 0.0399 mL | 0.1996 mL | 0.3992 mL | 0.9979 mL | |
| 30 mM | 0.0333 mL | 0.1663 mL | 0.3326 mL | 0.8316 mL | |
| 40 mM | 0.0249 mL | 0.1247 mL | 0.2495 mL | 0.6237 mL | |
| 50 mM | 0.0200 mL | 0.0998 mL | 0.1996 mL | 0.4989 mL | |
| 60 mM | 0.0166 mL | 0.0832 mL | 0.1663 mL | 0.4158 mL | |
| 80 mM | 0.0125 mL | 0.0624 mL | 0.1247 mL | 0.3118 mL |
DBCO-PEG12-NHS ester Related Classifications
HY-140274 Related Classifications
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