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Cat. No.: HY-185694

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DBCO2-SS2-PEG24

DBCO2-SS2-PEG24 is a bivalent shielding agent containing dibenzocyclooctyne (DBCO) and PEG24 domains, synthesized for copper-free click reaction-mediated postmodification of azide-bearing siRNA lipo-polyplexes.DBCO2-SS2-PEG24 can be used for the research of cervical carcinoma, hepatocellular carcinoma.

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CAS No.: 2304536-81-8
화학식: C₁₁₃H₁₇₃N₉O₃₅S₄
분자량:2345.88

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

DBCO2-SS2-PEG24 Chemical Structure

CAS No.: 2304536-81-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

DBCO₂-SS2-PEG₂₄ (0.25-1 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes maintain stable spherical morphology, provide effective charge shielding, exhibit good serum stability, and mediate moderate gene silencing in EGFR-overexpressing KB/eGFPLuc and Huh7/eGFPLuc cells^[1].
DBCO₂-SS2-PEG₂₄ (0.75 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes exhibit lower cellular internalization efficiency in EGFR-overexpressing KB and Huh7 cells compared to GE11-targeted DBCO-modified polyplexes^[1].
DBCO₂-SS2-PEG₂₄ (0.75 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes mediate moderate EG5 gene silencing and antitumoral activity in EGFR-overexpressing KB and Huh7 cells, with lower efficacy than GE11-targeted DBCO-modified polyplexes^[1].
DBCO₂-SS2-PEG₂₄ (0.75 equiv (mol/mol) relative to oligomer; 4 h) modified 1216 siRNA polyplexes induce moderate EG5 silencing-related mitotic arrest and apoptosis in EGFR-overexpressing KB and Huh7 cells, with lower potency than GE11-targeted DBCO-modified polyplexes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2304536-81-8
분자량 2345.88
화학식 C₁₁₃H₁₇₃N₉O₃₅S₄
SMILES

O=C(CCC(NCCSSCCCNC(CCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)CCCCNC(CCC(NCCCSSCCNC(CCC(N1CC2=CC=CC=C2C#CC3=CC=CC=C31)=O)=O)=O)=O)=O)=O)=O)N4CC5=CC=CC=C5C#CC6=CC=CC=C64
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Double Click-Functionalized siRNA Polyplexes for Gene Silencing in Epidermal Growth Factor Receptor-Positive Tumor Cells. ACS Biomater Sci Eng. 2020;6(2):1074-1089. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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