Cat. No.: HY-14648G

Dexamethasone (GMP)

(Synonyms: Hexadecadrol (GMP); Prednisolone F (GMP))

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor.

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CAS No.: 50-02-2
화학식: C₂₂H₂₉FO₅
분자량:392.46

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Dexamethasone (GMP) Chemical Structure

CAS No.: 50-02-2

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Biological Activity
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Biological Activity

제품 설명

All ADC Payloads Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	1 nM Compound: Dexamethasone	Activity at glucocorticoid receptor in human A549 cells assessed as effect on GRE promoter response by luciferase reporter assay Activity at glucocorticoid receptor in human A549 cells assessed as effect on GRE promoter response by luciferase reporter assay	[PMID: 16643060]
A549	EC₅₀	1.1 nM Compound: dex	Transrepression activity at GR in IL-1-beta-stimulated human A549 cells assessed as inhibition of NF-kappaB-dependent E-selectin transcription by luciferase reporter gene assay Transrepression activity at GR in IL-1-beta-stimulated human A549 cells assessed as inhibition of NF-kappaB-dependent E-selectin transcription by luciferase reporter gene assay	[PMID: 19321341]
A549	EC₅₀	2.5 nM Compound: dex	Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene activity Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene activity	[PMID: 19321341]
A549	EC₅₀	1.1 nM Compound: Dexamethasone	Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-selection promoter activation after 6 hrs by luciferase reporter gene based ELAM assay Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of IL-1-beta-induced NF-kappaB dependent E-selection promoter activation after 6 hrs by luciferase reporter gene based ELAM assay	[PMID: 20047280]
A549	EC₅₀	2.5 nM Compound: Dexamethasone	Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by luciferase reporter gene assay Transrepression activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of PMA-induced AP1 activity after 6 hrs by luciferase reporter gene assay	[PMID: 20047280]
A549	EC₅₀	1.1 nM Compound: 1, dex	Transrepression activity of glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay Transrepression activity of glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay	[PMID: 21073190]
A549	EC₅₀	2.5 nM Compound: 1, dex	Transrepression activity of glucocorticoid receptor in human A549 cells expressing AP-1 assessed as inhibition of PMA-induced AP-1 activity by luciferase reporter gene assay Transrepression activity of glucocorticoid receptor in human A549 cells expressing AP-1 assessed as inhibition of PMA-induced AP-1 activity by luciferase reporter gene assay	[PMID: 21073190]
A549	EC₅₀	1.1 nM Compound: Dex	Transrepression activity at glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay Transrepression activity at glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay	[PMID: 23916594]
A549	EC₅₀	2.5 nM Compound: Dex	Transrepression activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-stimulated AP1 response element by luciferase reporter gene assay Transrepression activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-stimulated AP1 response element by luciferase reporter gene assay	[PMID: 23916594]
A549	EC₅₀	1.1 nM Compound: 1, Dex	Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of IL-1beta-induced NF-kappaB dependent E-selectin activation by luciferase reporter gene assay Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of IL-1beta-induced NF-kappaB dependent E-selectin activation by luciferase reporter gene assay	[PMID: 23953070]
A549	EC₅₀	2.5 nM Compound: 1, Dex	Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-induced AP-1 activation by luciferase reporter gene assay Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-induced AP-1 activation by luciferase reporter gene assay	[PMID: 23953070]
A549	EC₅₀	2.5 nM Compound: Dexamethasone	Transrepression of glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-induced AP-1 activity by luciferase reporter gene assay Transrepression of glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-induced AP-1 activity by luciferase reporter gene assay	[PMID: 24011644]
A549	EC₅₀	1.1 nM Compound: 1, Dex	Agonist activity at glucocorticoid receptor in human A549 cells assessed as E-selectin transrepression by luciferase reporter gene assay Agonist activity at glucocorticoid receptor in human A549 cells assessed as E-selectin transrepression by luciferase reporter gene assay	[PMID: 24980053]
A549	EC₅₀	2.5 nM Compound: 1, Dex	Agonist activity at glucocorticoid receptor in human A549 cells assessed as AP-1 transrepression by luciferase reporter gene assay Agonist activity at glucocorticoid receptor in human A549 cells assessed as AP-1 transrepression by luciferase reporter gene assay	[PMID: 24980053]
A549	IC₅₀	>15 μM Compound: Dex	Anticancer against human A549 cells after 72 hrs by MTT assay Anticancer against human A549 cells after 72 hrs by MTT assay	[PMID: 24992071]
A549	EC₅₀	2.2 nM Compound: Dexamethasone	Inhibition of GM-CSF release in human A549 cells Inhibition of GM-CSF release in human A549 cells	[PMID: 37210838]
A549	IC₅₀	0.2 nM Compound: 3	Inhibition of IL-6 production in recombinant human IL-1 beta induced A549 cells preincubated with compound for 1 hr followed by IL-1 beta addition and measured after 20 hrs by MSD assay Inhibition of IL-6 production in recombinant human IL-1 beta induced A549 cells preincubated with compound for 1 hr followed by IL-1 beta addition and measured after 20 hrs by MSD assay	[PMID: 39240657]
A549	IC₅₀	0.2 nM Compound: 3	Inhibition of TNF alpha production in recombinant human IL-1 beta induced A549 cells preincubated with compound for 1 hr followed by IL-1 beta addition and measured after 20 hrs by MSD assay Inhibition of TNF alpha production in recombinant human IL-1 beta induced A549 cells preincubated with compound for 1 hr followed by IL-1 beta addition and measured after 20 hrs by MSD assay	[PMID: 39240657]
B16-F10	IC₅₀	>20 μM Compound: Dex	Anticancer against mouse B16F10 cells after 72 hrs by MTT assay Anticancer against mouse B16F10 cells after 72 hrs by MTT assay	[PMID: 24992071]
B-cell	IC₅₀	0.8 μM Compound: Dexamethasone	Immunosuppressive activity against BALB/C mouse B lymphocytes assessed as reduction in LPS-induced cell proliferation by measuring [3H]-thymidine uptake incubated for 8 hrs by Beta scintillation counting method Immunosuppressive activity against BALB/C mouse B lymphocytes assessed as reduction in LPS-induced cell proliferation by measuring [3H]-thymidine uptake incubated for 8 hrs by Beta scintillation counting method	[PMID: 31961677]
BV-2	IC₅₀	2.5 x 10^-2 μM Compound: Dexamethasone	Antiinflammatory activity in C57BL6/J mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in C57BL6/J mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 26110443]
BV-2	IC₅₀	9.5 μM Compound: Dexamethasone	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production	[PMID: 29482940]
BV-2	IC₅₀	2.83 μM Compound: Dexamethasone	Antineuroinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production by griess assay Antineuroinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production by griess assay	[PMID: 37530709]
BV-2	IC₅₀	9.47 μM Compound: Dexamethasone	Antineuroinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production pre-incubated for 2 hr followed by LPS-stimulation measured for 24 hrs by Griess reagent based analysis Antineuroinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production pre-incubated for 2 hr followed by LPS-stimulation measured for 24 hrs by Griess reagent based analysis	[PMID: 37683361]
BV-2	IC₅₀	9.5 μM Compound: Dexamethasone	Anti-inflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production pre-treated with compounds for 2 hrs followed by LPS-stimulation measured for 22 hrs by Griess reagent based analysis Anti-inflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production pre-treated with compounds for 2 hrs followed by LPS-stimulation measured for 22 hrs by Griess reagent based analysis	[PMID: 37683361]
CHO	IC₅₀	>20 μM Compound: Dex	Cytotoxicity against CHO cells after 72 hrs by MTT assay Cytotoxicity against CHO cells after 72 hrs by MTT assay	[PMID: 24992071]
COS-7	EC₅₀	7.2 nM Compound: Dexamethasone	Agonist activity at glucocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay Agonist activity at glucocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay	[PMID: 19863083]
CV-1	EC₅₀	0.2 nM Compound: dexamethasone	Agonist activity at human GR expressed in CV1 cells by GRE activation assay Agonist activity at human GR expressed in CV1 cells by GRE activation assay	[PMID: 17705362]
CV-1	ED₅₀	0.1 nM Compound: dexamethasone	Activity at human glucocorticoid receptor expressed in CV1 cells assessed as repression of TNF and IL-1-beta-induced E-selectin gene expression by luciferase reporter gene assay Activity at human glucocorticoid receptor expressed in CV1 cells assessed as repression of TNF and IL-1-beta-induced E-selectin gene expression by luciferase reporter gene assay	[PMID: 18032610]
Fibroblast	IC₅₀	>15 μM Compound: Dex	Cytotoxicity against mouse fibroblasts after 72 hrs by MTT assay Cytotoxicity against mouse fibroblasts after 72 hrs by MTT assay	[PMID: 24992071]
HEK293	IC₅₀	>500 μM Compound: dexamethasone	Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	[PMID: 23241029]
HEK293	EC₅₀	1.3 nM Compound: DEX	Agonist activity at human GCR expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at human GCR expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25305688]
HEK-293T	IC₅₀	>20 μM Compound: Dex	Cytotoxicity against HEK293T cells after 72 hrs by MTT assay Cytotoxicity against HEK293T cells after 72 hrs by MTT assay	[PMID: 24992071]
HEK-293T	CC₅₀	>200 μM Compound: DXMS	Cytotoxicity against TNF-alpha induced HEK293T cells assessed as inhibition of cell growth preincubated for 24 hrs followed by TNFalpha stimulation and measured after 4 hrs by SRB assay Cytotoxicity against TNF-alpha induced HEK293T cells assessed as inhibition of cell growth preincubated for 24 hrs followed by TNFalpha stimulation and measured after 4 hrs by SRB assay	[PMID: 37643546]
HeLa	EC₅₀	17 nM Compound: 1a	Activation of MMTV in HeLa cells measured by luciferase activity Activation of MMTV in HeLa cells measured by luciferase activity	[PMID: 17181172]
HeLa	EC₅₀	4.5 nM Compound: Dexamethasone	Transactivation of GAL-4 tagged glucocorticoid receptor ligand binding domain expressed in human HeLa cells assessed as NP1 activation by luciferase reporter gene assay Transactivation of GAL-4 tagged glucocorticoid receptor ligand binding domain expressed in human HeLa cells assessed as NP1 activation by luciferase reporter gene assay	[PMID: 20047280]
HeLa	EC₅₀	4.2 nM Compound: 1, dex	Transactivation activity of glucocorticoid receptor ligand binding domain expressed in human NP-1 Hela cells co-expressing GAL4 DNA binding domain by luciferase reporter gene assay Transactivation activity of glucocorticoid receptor ligand binding domain expressed in human NP-1 Hela cells co-expressing GAL4 DNA binding domain by luciferase reporter gene assay	[PMID: 21073190]
HeLa	EC₅₀	17 nM Compound: Dexamethasone	Agonist activity at glucocorticoid receptor in human HeLa cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity Agonist activity at glucocorticoid receptor in human HeLa cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity	[PMID: 21963986]
HeLa	EC₅₀	4.5 nM Compound: Dex	Transactivation activity at glucocorticoid receptor ligand binding domain (unknown origin) expressed in human Hela cells co-expressing GAL4 DNA binding domain assessed as NP-1-stimulated GRE activation by luciferase reporter gene assay Transactivation activity at glucocorticoid receptor ligand binding domain (unknown origin) expressed in human Hela cells co-expressing GAL4 DNA binding domain assessed as NP-1-stimulated GRE activation by luciferase reporter gene assay	[PMID: 23916594]
HeLa	EC₅₀	4.5 nM Compound: 1, Dex	Transactivation of glucocorticoid receptor ligand binding domain (unknown origin) transfected in human HeLa cells assessed as activation of NP-1 by GAL4 luciferase reporter gene assay Transactivation of glucocorticoid receptor ligand binding domain (unknown origin) transfected in human HeLa cells assessed as activation of NP-1 by GAL4 luciferase reporter gene assay	[PMID: 23953070]
HeLa	EC₅₀	4.2 nM Compound: Dexamethasone	Transactivation of GR-LBD expressed in human HeLa cells co-expressing GAL4-DBD by luciferase reporter gene assay Transactivation of GR-LBD expressed in human HeLa cells co-expressing GAL4-DBD by luciferase reporter gene assay	[PMID: 24011644]
HeLa	EC₅₀	17 nM Compound: Dexamethasone	Transactivation of glucocorticoid receptor in human HeLa cells harboring MMTV promoter by luciferase reporter gene assay Transactivation of glucocorticoid receptor in human HeLa cells harboring MMTV promoter by luciferase reporter gene assay	[PMID: 24656565]
HeLa	EC₅₀	4.5 nM Compound: 1, Dex	Agonist activity at glucocorticoid receptor in human HeLa cells assessed as NP-1 transactivation by luciferase reporter gene assay Agonist activity at glucocorticoid receptor in human HeLa cells assessed as NP-1 transactivation by luciferase reporter gene assay	[PMID: 24980053]
HeLa S3	IC₅₀	4.1 nM Compound: dexamethasone	Displacement of [3H]Dexamethasone from glucocorticoid receptor in human HeLaS3 cells after 2 hrs Displacement of [3H]Dexamethasone from glucocorticoid receptor in human HeLaS3 cells after 2 hrs	[PMID: 23403082]
HepG2	EC₅₀	2.6 μM Compound: Dexamethasone	Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis	[PMID: 20966043]
HFF	EC₅₀	1.9 nM Compound: 1a	Induction of aromatase activity in HFF cells assessed as production of beta estradiol by aromatase assay Induction of aromatase activity in HFF cells assessed as production of beta estradiol by aromatase assay	[PMID: 17181172]
HFF	IC₅₀	0.51 nM Compound: 1a	Inhibition of IL1-stimulated IL6 production in HFF cells Inhibition of IL1-stimulated IL6 production in HFF cells	[PMID: 17181172]
HFF	EC₅₀	0.5 nM Compound: dexamethasone	Antiinflammatory activity assessed as inhibition of IL1 stimulated IL6 production in HFF cells by transrepression assay Antiinflammatory activity assessed as inhibition of IL1 stimulated IL6 production in HFF cells by transrepression assay	[PMID: 17692519]
HFF	EC₅₀	2 nM Compound: dexamethasone	Antiinflammatory activity assessed as upregulation of aromatase in HFF cells by transactivation assay Antiinflammatory activity assessed as upregulation of aromatase in HFF cells by transactivation assay	[PMID: 17692519]
HFF	IC₅₀	1 nM Compound: Dexamethasone	Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production	[PMID: 25516791]
Huh-7	EC₅₀	5 nM Compound: 1, dex	Transactivation activity at glucocorticoid receptor in human 13D3/Huh7 cells assessed as induction of tyrosine aminotransferase activity after 24 hrs Transactivation activity at glucocorticoid receptor in human 13D3/Huh7 cells assessed as induction of tyrosine aminotransferase activity after 24 hrs	[PMID: 21073190]
IM-9	IC₅₀	3.8 nM Compound: Dexamethasone	Displacement of [3H]dexamethasone from glucocorticoid receptor in human IM9 cells Displacement of [3H]dexamethasone from glucocorticoid receptor in human IM9 cells	[PMID: 26988801]
IM-9	IC₅₀	3.8 x 10^-9 M Compound: Dexamethasone	Displacement of [3H]dexamethasone from GR receptor in human IM9 cells Displacement of [3H]dexamethasone from GR receptor in human IM9 cells	[PMID: 27876250]
J774	IC₅₀	169.5 μM Compound: Dexamethasone	Inhibitory activity against nitric oxide production in lipopolysaccharide (LPS)-activated macrophage -like J774.1 cell Inhibitory activity against nitric oxide production in lipopolysaccharide (LPS)-activated macrophage -like J774.1 cell	[PMID: 12467611]
J774	CC₅₀	91.1 μM Compound: Dexa	Cytotoxicity against BALB/c mouse J774 cells assessed as reduction in cell viability after 72 hrs by alamarBlue assay Cytotoxicity against BALB/c mouse J774 cells assessed as reduction in cell viability after 72 hrs by alamarBlue assay	[PMID: 29523468]
J774	IC₅₀	5.2 μM Compound: Dexamethasone	Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS/IFNgamma-induced NO production incubated for 24 hrs by Griess method Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS/IFNgamma-induced NO production incubated for 24 hrs by Griess method	[PMID: 32364737]
J774.1	IC₅₀	170 μM Compound: dexamethasone	Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs	[PMID: 12608860]
J774.A1	IC₅₀	48 nM Compound: dexamethasone	Inhibition of LPS-induced TNFalpha production in mouse J774A.1 cells Inhibition of LPS-induced TNFalpha production in mouse J774A.1 cells	[PMID: 17892941]
J774.A1	IC₅₀	0.165 μg/mL Compound: Dexamethasone	Inhibition of LPS-induced TNF-alpha release in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment measured after 6 to 12 hrs by sandwich immunoassay Inhibition of LPS-induced TNF-alpha release in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment measured after 6 to 12 hrs by sandwich immunoassay	[PMID: 25113933]
J774.A1	IC₅₀	9.09 μg/mL Compound: Dexamethasone	Inhibition of LPS-induced IL1-beta release in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment measured after 6 to 12 hrs by sandwich immunoassay Inhibition of LPS-induced IL1-beta release in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment measured after 6 to 12 hrs by sandwich immunoassay	[PMID: 25113933]
J774.A1	IC₅₀	0.4 μM Compound: DEXA	Inhibition of TNFalpha production in mouse J774A.1 cells incubated for 6 hrs by sandwich immunoassay Inhibition of TNFalpha production in mouse J774A.1 cells incubated for 6 hrs by sandwich immunoassay	[PMID: 25824662]
J774.A1	IC₅₀	22 μM Compound: DEXA	Inhibition of IL-1beta production in mouse J774A.1 cells incubated for 12 hrs by sandwich immunoassay Inhibition of IL-1beta production in mouse J774A.1 cells incubated for 12 hrs by sandwich immunoassay	[PMID: 25824662]
L02	IC₅₀	4620.58 μM Compound: Dex	Antiinflammatory activity against human L02 assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess assay relative to control Antiinflammatory activity against human L02 assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess assay relative to control	[PMID: 33515864]
L02	IC₅₀	4620.58 μM Compound: Dex	Cytotoxicity against human L02 cells cells assessed as cell viability by MTT assay Cytotoxicity against human L02 cells cells assessed as cell viability by MTT assay	[PMID: 33515864]
LLC-PK1	IC₅₀	>50 μM Compound: Dexamethasone	Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
LLC-PK1	IC₅₀	>50 μM Compound: Dexamethasone	Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
LLC-PK1	IC₅₀	>50 μM Compound: Dexamethasone	Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
LLC-PK1	IC₅₀	>50 μM Compound: Dexamethasone	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells	[PMID: 12699389]
LLC-PK1	IC₅₀	>50 μM Compound: Dexamethasone	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells	[PMID: 12699389]
LLC-PK1	IC₅₀	>50 μM Compound: Dexamethasone	TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells	[PMID: 12699389]
Macrophage	IC₅₀	0.134 μM Compound: Dexamethasone	Inhibition of TNFalpha expression in LPS-induced macrophages (unknown origin) incubated for 24 hrs by ELISA Inhibition of TNFalpha expression in LPS-induced macrophages (unknown origin) incubated for 24 hrs by ELISA	[PMID: 31473042]
MCF7	IC₅₀	>15 μM Compound: Dex	Anticancer against human MCF7 cells after 72 hrs by MTT assay Anticancer against human MCF7 cells after 72 hrs by MTT assay	[PMID: 24992071]
Multiple myeloma cancer stem cell	IC₅₀	>100000 nM Compound: DEX	Antiproliferative activity against human multiple myeloma cancer stem cells after 72 hrs by MTT assay Antiproliferative activity against human multiple myeloma cancer stem cells after 72 hrs by MTT assay	[PMID: 30108696]
N9	IC₅₀	0.074 μM Compound: Dexamethasone	Inhibitory activity against TNF-alpha release in N9 cells in the supernatant Inhibitory activity against TNF-alpha release in N9 cells in the supernatant	[PMID: 12361395]
PBMC	EC₅₀	>0.2 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced MCP-1 production after 24 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced MCP-1 production after 24 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.001 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-5 production after 48 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-5 production after 48 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0012 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-13 production after 24 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-13 production after 24 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0019 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced TNFalpha production after 48 hrs Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced TNFalpha production after 48 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0021 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced IL-1beta production after 48 hrs Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced IL-1beta production after 48 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0024 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IP-10 production after 24 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IP-10 production after 24 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0035 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-3 production after 48 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-3 production after 48 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0036 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-2 production after 48 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-2 production after 48 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0041 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced IL-12p70 production after 48 hrs Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced IL-12p70 production after 48 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0055 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-10 production after 48 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-10 production after 48 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0061 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced TNFalpha production after 6 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced TNFalpha production after 6 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0076 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IFNgamma production after 24 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IFNgamma production after 24 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.0094 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-1beta production after 6 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-1beta production after 6 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.01 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 6 hrs Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 6 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.014 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-1beta production after 6 hrs Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-1beta production after 6 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.055 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-6 production after 6 hrs Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-6 production after 6 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.066 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced MIP1alpha production after 6 hrs Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced MIP1alpha production after 6 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.072 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-8 production after 6 hrs Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-8 production after 6 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.082 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-6 production after 6 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-6 production after 6 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.088 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-8 production after 6 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-8 production after 6 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.13 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced MIP1alpha production after 6 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced MIP1alpha production after 6 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.00047 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced GM-CSF production after 48 hrs Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced GM-CSF production after 48 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.00092 μM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-4 production after 24 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-4 production after 24 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.47 nM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced GM-CSF production after 48 hrs Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced GM-CSF production after 48 hrs	[PMID: 23199485]
PBMC	EC₅₀	0.92 nM Compound: 1	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-4 production after 24 hrs Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IL-4 production after 24 hrs	[PMID: 23199485]
PBMC	IC₅₀	0.0095 μM Compound: Dexamethasone	Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced IL1-beta release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced IL1-beta release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay	[PMID: 23411072]
PBMC	IC₅₀	0.017 μM Compound: Dexamethasone	Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced TNFalpha release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced TNFalpha release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay	[PMID: 23411072]
PBMC	IC₅₀	0.002 μM Compound: dexamethasone	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha expression pretreated 1 hr before LPS challenge followed by incubated for 16 hrs by flow cytometry Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha expression pretreated 1 hr before LPS challenge followed by incubated for 16 hrs by flow cytometry	[PMID: 25338180]
PBMC	IC₅₀	0.008 μM Compound: dexamethasone	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-1beta expression pretreated 1 hr before LPS challenge followed by incubated for 16 hrs by flow cytometry Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-1beta expression pretreated 1 hr before LPS challenge followed by incubated for 16 hrs by flow cytometry	[PMID: 25338180]
PBMC	IC₅₀	0.009 μM Compound: dexamethasone	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-8 expression pretreated 1 hr before LPS challenge followed by incubated for 16 hrs by flow cytometry Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-8 expression pretreated 1 hr before LPS challenge followed by incubated for 16 hrs by flow cytometry	[PMID: 25338180]
PBMC	IC₅₀	2.3 nM Compound: Dexamethasone	Inhibition of PHA-induced IL4 release in human PBMC cells Inhibition of PHA-induced IL4 release in human PBMC cells	[PMID: 32631518]
PBMC	IC₅₀	3.8 nM Compound: Dexamethasone	Inhibition of PHA-induced IFNgamma release in human PBMC cells Inhibition of PHA-induced IFNgamma release in human PBMC cells	[PMID: 32631518]
PBMC	IC₅₀	4.3 nM Compound: Dexamethasone	Inhibition of LPS-induced IL12p40 release in human PBMC cells Inhibition of LPS-induced IL12p40 release in human PBMC cells	[PMID: 32631518]
PBMC	IC₅₀	4.6 nM Compound: Dexamethasone	Inhibition of PHA-induced IL2 release in human PBMC cells Inhibition of PHA-induced IL2 release in human PBMC cells	[PMID: 32631518]
PBMC	IC₅₀	6.4 nM Compound: Dexamethasone	Inhibition of LPS-induced TNFalpha release in human PBMC cells Inhibition of LPS-induced TNFalpha release in human PBMC cells	[PMID: 32631518]
PBMC	IC₅₀	3.6 nM Compound: Dexamethasone	Inhibition of TNF-alpha production in LPS-stimulated human PBMC measured after 24 hrs by ELISA Inhibition of TNF-alpha production in LPS-stimulated human PBMC measured after 24 hrs by ELISA	[PMID: 35870364]
Peritoneal macrophage	IC₅₀	0.15 μM Compound: Dexamethasone	Anti-inflammatory activity in mouse peritoneal macrophages assessed as inhibition of LPS-induced NO production incubated for 22 hrs by Griess reagent based colorimetric assay Anti-inflammatory activity in mouse peritoneal macrophages assessed as inhibition of LPS-induced NO production incubated for 22 hrs by Griess reagent based colorimetric assay	[PMID: 31358465]
R1	IC₅₀	5 nM Compound: Dexamethasone	Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression at 10 uM after 24 hrs by beta-galactosidase assay Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression at 10 uM after 24 hrs by beta-galactosidase assay	[PMID: 18412397]
RAW	IC₅₀	20 nM Compound: DXM	Inhibition of interferon gamma-stimulated NO production in RAW 264.7 cells after 24 hrs Inhibition of interferon gamma-stimulated NO production in RAW 264.7 cells after 24 hrs	[PMID: 17367124]
RAW264.7	IC₅₀	0.7 μM Compound: dexamethasone	Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as effect on TNFalpha formation pretreated 1 hr before LPS challenge measured after 24 hrs Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as effect on TNFalpha formation pretreated 1 hr before LPS challenge measured after 24 hrs	[PMID: 11908984]
RAW264.7	IC₅₀	0.42 μM Compound: Dexamethasone	Inhibitory activity against TNF-alpha release in RAW 264.7 cells in the supernatant Inhibitory activity against TNF-alpha release in RAW 264.7 cells in the supernatant	[PMID: 12361395]
RAW264.7	IC₅₀	>25 μg/mL Compound: Dexamethasone	Cytotoxicity against mouse RAW264.7 cells after 2 days by MTT assay Cytotoxicity against mouse RAW264.7 cells after 2 days by MTT assay	[PMID: 15165136]
RAW264.7	IC₅₀	36 μg/mL Compound: Dexamethasone	Inhibition of iNOS production in LPS-activated mouse RAW264.7 cells after 20 hrs Inhibition of iNOS production in LPS-activated mouse RAW264.7 cells after 20 hrs	[PMID: 15165136]
RAW264.7	IC₅₀	0.86 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 2 hrs before LPS challenge measured after 18 hrs by griess reaction Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 2 hrs before LPS challenge measured after 18 hrs by griess reaction	[PMID: 21288727]
RAW264.7	IC₅₀	0.01 μM Compound: Dexsamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 18 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 18 hrs	[PMID: 21353543]
RAW264.7	IC₅₀	0.8 μM Compound: Dexsamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method	[PMID: 21353543]
RAW264.7	IC₅₀	20 nM Compound: DXM	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma induced NO production after 24 hrs by Griess reaction Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma induced NO production after 24 hrs by Griess reaction	[PMID: 21361338]
RAW264.7	IC₅₀	0.47 μM Compound: Hexadecadrol	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production pretreated for 2 hrs before LPS challenge measured after 18 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production pretreated for 2 hrs before LPS challenge measured after 18 hrs by Griess method	[PMID: 22372956]
RAW264.7	IC₅₀	0.98 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 2 hrs before LPS challenge measured after 18 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 2 hrs before LPS challenge measured after 18 hrs by Griess method	[PMID: 22537362]
RAW264.7	IC₅₀	1.43 μM Compound: dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 2 hrs prior to LPS-challenge measured after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 2 hrs prior to LPS-challenge measured after 24 hrs by Griess method	[PMID: 23373965]
RAW264.7	IC₅₀	0.016 μg/mL Compound: Dexamethasone	Inhibition of LPS-induced TNF-alpha release in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment measured after 6 to 12 hrs by sandwich immunoassay Inhibition of LPS-induced TNF-alpha release in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment measured after 6 to 12 hrs by sandwich immunoassay	[PMID: 25113933]
RAW264.7	IC₅₀	1.84 μg/mL Compound: Dexamethasone	Inhibition of LPS-induced IL1-beta release in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment measured after 6 to 12 hrs by sandwich immunoassay Inhibition of LPS-induced IL1-beta release in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment measured after 6 to 12 hrs by sandwich immunoassay	[PMID: 25113933]
RAW264.7	IC₅₀	0.8 μM Compound: Dexamethasone	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay relative to vehicle-treated control Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay relative to vehicle-treated control	[PMID: 25499882]
RAW264.7	IC₅₀	0.04 μM Compound: DEXA	Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay Inhibition of TNFalpha production in mouse RAW264.7 cells incubated for 6 hrs by sandwich immunoassay	[PMID: 25824662]
RAW264.7	IC₅₀	4.7 μM Compound: DEXA	Inhibition of IL-1beta production in mouse RAW264.7 cells incubated for 12 hrs by sandwich immunoassay Inhibition of IL-1beta production in mouse RAW264.7 cells incubated for 12 hrs by sandwich immunoassay	[PMID: 25824662]
RAW264.7	IC₅₀	0.63 μM Compound: dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 26087384]
RAW264.7	IC₅₀	0.8 μM Compound: dexamethasone	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 26305406]
RAW264.7	IC₅₀	0.63 μM Compound: DXM	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs in presence of LPS by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs in presence of LPS by Griess assay	[PMID: 27825545]
RAW264.7	IC₅₀	7 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay	[PMID: 28499733]
RAW264.7	IC₅₀	2.5 μM Compound: Dexamethasone	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 28598633]
RAW264.7	IC₅₀	0.8 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by griess assay	[PMID: 29272126]
RAW264.7	IC₅₀	10.7 μM Compound: Dexamethasone	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 29518326]
RAW264.7	IC₅₀	8.3 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production	[PMID: 29741372]
RAW264.7	IC₅₀	2.66 μM Compound: Dex	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess assay	[PMID: 30108912]
RAW264.7	CC₅₀	>50 μM Compound: Dexamethasone	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by CCK8 assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by CCK8 assay	[PMID: 30528697]
RAW264.7	IC₅₀	8.7 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production pretreated for 30 mins followed by LPS stimulation for 24 hrs by ELISA Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production pretreated for 30 mins followed by LPS stimulation for 24 hrs by ELISA	[PMID: 30528697]
RAW264.7	IC₅₀	1.2 μM Compound: DEX	Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced TNF-alpha production after 48 hrs by ELISA Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced TNF-alpha production after 48 hrs by ELISA	[PMID: 30579802]
RAW264.7	IC₅₀	9.4 μM Compound: DEX	Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 production after 48 hrs by ELISA Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 production after 48 hrs by ELISA	[PMID: 30579802]
RAW264.7	IC₅₀	0.13 μM Compound: Dexamethasone	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess reagent-based assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess reagent-based assay	[PMID: 30808589]
RAW264.7	IC₅₀	7.9 μM Compound: Dexamethasone	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 3 hrs followed by LPS-stimulation and measured after 24 hrs by Griess assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 3 hrs followed by LPS-stimulation and measured after 24 hrs by Griess assay	[PMID: 30817151]
RAW264.7	IC₅₀	0.01 μM Compound: Dexamethasone	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 30 mins followed by LPS-stimulation and measured after 24 hrs by Griess assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 30 mins followed by LPS-stimulation and measured after 24 hrs by Griess assay	[PMID: 30931559]
RAW264.7	IC₅₀	18.4 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 12 hrs followed by LPS-stimulation and measured after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 12 hrs followed by LPS-stimulation and measured after 24 hrs by Griess assay	[PMID: 31181925]
RAW264.7	IC₅₀	159.2 μM Compound: Dexamethasone	Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell viability preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by WST-1 assay Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell viability preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by WST-1 assay	[PMID: 31260892]
RAW264.7	IC₅₀	5.02 μM Compound: Dexamethasone	Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO overproduction preincubated for 1 hr prior to Escherichia coli LPS stimulation followed by further incubation for 24 hrs by Griess reagent based spectrophotome Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO overproduction preincubated for 1 hr prior to Escherichia coli LPS stimulation followed by further incubation for 24 hrs by Griess reagent based spectrophotome	[PMID: 31260892]
RAW264.7	IC₅₀	0.01 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay	[PMID: 31301930]
RAW264.7	IC₅₀	6 μM Compound: Dexamethasone	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent-based assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent-based assay	[PMID: 31577434]
RAW264.7	IC₅₀	6.1 μM Compound: Dexamethasone	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 24 hrs by ELISA Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 24 hrs by ELISA	[PMID: 31577434]
RAW264.7	IC₅₀	8.4 μM Compound: Dexamethasone	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 secretion after 24 hrs by ELISA Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 secretion after 24 hrs by ELISA	[PMID: 31577434]
RAW264.7	IC₅₀	5.5 μM Compound: Dexamethasone	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production	[PMID: 31873014]
RAW264.7	IC₅₀	32.5 μM Compound: DXMS	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay	[PMID: 32070636]
RAW264.7	IC₅₀	0.62 μM Compound: Dexamethasone	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs	[PMID: 32485533]
RAW264.7	IC₅₀	4.16 μM Compound: Dexamethasone	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production	[PMID: 32738985]
RAW264.7	IC₅₀	0.62 μM Compound: Dexamethasone	Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of LPS induced NO production Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of LPS induced NO production	[PMID: 32795767]
RAW264.7	IC₅₀	24.3 μM Compound: Dexamethasone	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS addition and measured after 18 hrs by Griess reagent-based assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS addition and measured after 18 hrs by Griess reagent-based assay	[PMID: 32935986]
RAW264.7	IC₅₀	47 μM Compound: Dexamethasone	Inhibition of NO production in LPS-induced mouse RAW264.7 cells Inhibition of NO production in LPS-induced mouse RAW264.7 cells	[PMID: 33454546]
RAW264.7	IC₅₀	>50 μM Compound: Dex	Cytotoxicity against LPS-induced mouse RAW 264.7 cells assessed as cell viability measured by MTT assay Cytotoxicity against LPS-induced mouse RAW 264.7 cells assessed as cell viability measured by MTT assay	[PMID: 33515864]
RAW264.7	IC₅₀	>50 μM Compound: Dex	Cytotoxicity against mouse RAW 264.7 cells assessed as cell viability by MTT assay Cytotoxicity against mouse RAW 264.7 cells assessed as cell viability by MTT assay	[PMID: 33515864]
RAW264.7	IC₅₀	8.71 μM Compound: Dex	Inhibition of LPS-induced NO release in mouse RAW264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO release in mouse RAW264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay	[PMID: 33515864]
RAW264.7	IC₅₀	8.28 μM Compound: Dexamethasone	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent-based assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent-based assay	[PMID: 33667092]
RAW264.7	IC₅₀	6.9 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs in presence of LPS by Griess reagent-based assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs in presence of LPS by Griess reagent-based assay	[PMID: 33914536]
RAW264.7	IC₅₀	14.75 μM Compound: Dexamethasone	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs by Griess assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs by Griess assay	[PMID: 33933753]
RAW264.7	IC₅₀	0.58 μM Compound: Dex	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 3 hrs followed by LPS-stimulation and measured after 24 hrs by Griess reagent based assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 3 hrs followed by LPS-stimulation and measured after 24 hrs by Griess reagent based assay	[PMID: 34333975]
RAW264.7	IC₅₀	22.2 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess reagent assay Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs by Griess reagent assay	[PMID: 35007071]
RAW264.7	IC₅₀	7.9 μM Compound: Dexamethasone	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay	[PMID: 35063896]
RAW264.7	IC₅₀	159.2 μM Compound: Dexamethasone	Cytotoxicity against mouse RAW264.7 by WST-1 vital dye reagent method Cytotoxicity against mouse RAW264.7 by WST-1 vital dye reagent method	[PMID: 35567964]
RAW264.7	IC₅₀	5.02 μM Compound: Dexamethasone	Inhibition of NO release in mouse RAW264.7 incubated for 15 mins by fluoroscence-luminescence reader infinite M200 Pro analysis Inhibition of NO release in mouse RAW264.7 incubated for 15 mins by fluoroscence-luminescence reader infinite M200 Pro analysis	[PMID: 35567964]
RAW264.7	CC₅₀	4.4 μM Compound: Dexamethasone	Cytotoxicity in LPS-stimulated mouse RAW264.7 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue dye based colorimetric assay Cytotoxicity in LPS-stimulated mouse RAW264.7 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue dye based colorimetric assay	[PMID: 35998343]
RAW264.7	IC₅₀	7.9 μM Compound: Dexamethasone	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 3 hrs followed by LPS addition and measured after 24 hrs Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 3 hrs followed by LPS addition and measured after 24 hrs	[PMID: 37002536]
RAW264.7	IC₅₀	11.5 μM Compound: Dexamethasone	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 24 hrs followed by LPS stimulation by Griess reagent-based colorimetric assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 24 hrs followed by LPS stimulation by Griess reagent-based colorimetric assay	[PMID: 37043994]
RAW264.7	IC₅₀	2.6 μM Compound: Dexamethasone	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 30 mins followed by LPS-stimulation and measured after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 30 mins followed by LPS-stimulation and measured after 24 hrs by Griess assay	[PMID: 37369059]
RAW264.7	IC₅₀	>50 μM Compound: Dexamethasone	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of NO release Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of NO release	[PMID: 37852423]
RAW264.7	IC₅₀	2 μM Compound: Dexamethasone	Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 10 uM preincubated with compound for 2 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 10 uM preincubated with compound for 2 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis	[PMID: 37856864]
RAW264.7	IC₅₀	6.7 μM Compound: Dexamethasone	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production preincubated with compound for 2 hrs followed by LPS stimulation and measured after 12 hrs by Griess reagent based microplate reader analysis Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production preincubated with compound for 2 hrs followed by LPS stimulation and measured after 12 hrs by Griess reagent based microplate reader analysis	[PMID: 38117952]
RAW264.7	IC₅₀	3.8 μM Compound: DXM	Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs incubation by Griess assay Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs incubation by Griess assay	[PMID: 38704943]
RAW264.7	IC₅₀	8.52 μM Compound: Dex	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based assay	[PMID: 38986603]
RAW264.7	IC₅₀	6.9 μM Compound: Dexamethasone	Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production preincubated for 2 hrs followed by LPS-stimulation and measured after 12 hrs by Griess reagent assay Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production preincubated for 2 hrs followed by LPS-stimulation and measured after 12 hrs by Griess reagent assay	[PMID: 39051441]
RAW264.7	IC₅₀	>40 μM Compound: Dexamethasone	Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell viability by MTT assay relative to control Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell viability by MTT assay relative to control	[PMID: 39149113]
RAW264.7	IC₅₀	11.04 μM Compound: Dexamethasone	Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS addition and measured after 24 hrs by Griess assay relative to control Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS addition and measured after 24 hrs by Griess assay relative to control	[PMID: 39149113]
RAW264.7	IC₅₀	355.14 μM Compound: dexamethasone	Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of PMA-induced macrophages respiratory burst measured up to 30 min by chemiluminescence method Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of PMA-induced macrophages respiratory burst measured up to 30 min by chemiluminescence method	10.1007/s00044-013-0504-9
REH	EC₅₀	6.7 nM Compound: Dexamethasone	Cytotoxicity against human REH cells overexpressing GR assessed as reduction in cell viability measured after 3 days by resazurin based assay Cytotoxicity against human REH cells overexpressing GR assessed as reduction in cell viability measured after 3 days by resazurin based assay	[PMID: 34046609]
RPMI-8226	IC₅₀	6.5 nM Compound: dexamethasone	Antiproliferative activity against human RPMI8226 cells after 4 days Antiproliferative activity against human RPMI8226 cells after 4 days	[PMID: 17705362]
Sf21	IC₅₀	137.4 μM Compound: Dexamethasone	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Sf21	IC₅₀	231.9 μM Compound: Dexamethasone	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Splenocyte	IC₅₀	0.001 μM Compound: Dexa	Immunomodulatory activity in BALB/c mouse splenocytes assessed as inhibition of concanavalin A-induced lymphocyte proliferation by measuring [3H]-thymidine uptake after 48 to 72 hrs by scintillation counting analysis Immunomodulatory activity in BALB/c mouse splenocytes assessed as inhibition of concanavalin A-induced lymphocyte proliferation by measuring [3H]-thymidine uptake after 48 to 72 hrs by scintillation counting analysis	[PMID: 29523468]
Splenocyte	IC₅₀	0.04 μM Compound: Dexamethasone	Immunosuppressive activity in BALB/c mouse splenocytes assessed as inhibition of ConA-induced T cell proliferation incubated for 48 hrs by CCK-8 assay Immunosuppressive activity in BALB/c mouse splenocytes assessed as inhibition of ConA-induced T cell proliferation incubated for 48 hrs by CCK-8 assay	[PMID: 39051441]
Splenocyte	IC₅₀	0.47 μM Compound: Dexamethasone	Immunosuppressive activity in BALB/c mouse splenocytes assessed as inhibition of LPS-induced B cell proliferation incubated for 48 hrs by CCK-8 assay Immunosuppressive activity in BALB/c mouse splenocytes assessed as inhibition of LPS-induced B cell proliferation incubated for 48 hrs by CCK-8 assay	[PMID: 39051441]
SW1353	IC₅₀	1.8 nM Compound: DEX	Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by ELISA Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by ELISA	[PMID: 25706100]
T-cell	IC₅₀	0.005 μM Compound: Dexamethasone	Inhibitory concentration against T cell proliferation using concanavalin A stimulated mice spleen cells Inhibitory concentration against T cell proliferation using concanavalin A stimulated mice spleen cells	[PMID: 11229767]
T-cell	IC₅₀	1.6 μM Compound: Dexamethasone	Immunosuppressive activity against BALB/C mouse T lymphocytes assessed as reduction in concanavalin A-induced cell proliferation by measuring [3H]-thymidine uptake incubated for 8 hrs by Beta scintillation counting method Immunosuppressive activity against BALB/C mouse T lymphocytes assessed as reduction in concanavalin A-induced cell proliferation by measuring [3H]-thymidine uptake incubated for 8 hrs by Beta scintillation counting method	[PMID: 31961677]
THP-1	IC₅₀	>100 μM Compound: dexamethasone	Cytotoxicity against human THP1 cells Cytotoxicity against human THP1 cells	[PMID: 18625560]
THP-1	IC₅₀	0.007 μM Compound: dexamethasone	Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL6 by ELISA Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL6 by ELISA	[PMID: 18625560]
THP-1	IC₅₀	0.05 μM Compound: dexamethasone	Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha by ELISA Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha by ELISA	[PMID: 18625560]
THP-1	IC₅₀	>=80 μM Compound: Dex	Cytotoxicity against human THP-1 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay Cytotoxicity against human THP-1 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay	[PMID: 38687956]

In Vitro

Dexamethasone (GMP) (100 nM; 10 d) increases myotubes formation and cytoplasmic lipid droplets accumulation of RCJ 3.1 cells^[1].
Dexamethasone (GMP) (10 nM-1 μM; 0-6 d) induces osteogenesis of chick periosteum cells with an optimal concentration of 100 nM^[2].
Dexamethasone (GMP) (10 μM) induces osteoblastic differentiation^[3].
Dexamethasone (GMP) (10 nM) stimulates differentiation of odontoblast-like cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 50-02-2
Appearance Solid
분자량 392.46
화학식 C₂₂H₂₉FO₅
Color White to off-white
SMILES

O=C1C=C[C@]2(C(CC[C@@]3([C@@]2([C@H](C[C@]4([C@]3(C[C@H]([C@]4(O)C(CO)=O)C)[H])C)O)F)[H])=C1)C
Synonyms

Hexadecadrol (GMP); Prednisolone F (GMP)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Antioxidants (Basel)

Lactobacillus plantarum-Derived Inorganic Polyphosphate Regulates Immune Function via Inhibiting M1 Polarization and Resisting Oxidative Stress in Macrophages. [Abstract]

2025 Apr 1;14(4):428. PMID: 40298816
Biochem Pharmacol

Circadian rhythm disturbance induces osteoarthritis in mice: Involvement of Clock and Bmal1 dysregulation and Pdgfa inhibition. [Abstract]

2025 Sep 17;242(Pt 3):117342. PMID: 40972737
Mol Cell Biochem

HIRA promotes osteogenic differentiation of BMSCs and ameliorates osteoporosis by mediating M2 polarization of macrophages through the YAP1/β-catenin pathway. [Abstract]

2026 Jun;481(6):2449-2466. PMID: 42048035
J Asthma

Tanshinone IIA attenuates airway inflammation and airway remodeling in bronchial asthma by inhibiting p38/NF-κB and AKT/HIF-1α. [Abstract]

2025 Dec 22:1-13. PMID: 41427969

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (254.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5480 mL

12.7402 mL

25.4803 mL

5 mM

0.5096 mL

2.5480 mL

5.0961 mL

10 mM

0.2548 mL

1.2740 mL

2.5480 mL

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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농도 희석 계산기

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순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (419 KB)
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- Norwegian - NO (419 KB)
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- Italian - IT (419 KB)
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- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Grigoriadis AE, et al. Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone. J Cell Biol. 1988 Jun;106(6):2139-51. [Content Brief]

[2]. Tenenbaum HC, Heersche JN. Dexamethasone stimulates osteogenesis in chick periosteum in vitro. Endocrinology. 1985 Nov;117(5):2211-7. [Content Brief]

[3]. Rickard DJ, et al. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol. 1994 Jan;161(1):218-28. [Content Brief]

[4]. Alliot-Licht B, et al. Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures. Cell Tissue Res. 2005 Sep;321(3):391-400. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5480 mL	12.7402 mL	25.4803 mL	63.7008 mL
	5 mM	0.5096 mL	2.5480 mL	5.0961 mL	12.7402 mL
	10 mM	0.2548 mL	1.2740 mL	2.5480 mL	6.3701 mL
	15 mM	0.1699 mL	0.8493 mL	1.6987 mL	4.2467 mL
	20 mM	0.1274 mL	0.6370 mL	1.2740 mL	3.1850 mL
	25 mM	0.1019 mL	0.5096 mL	1.0192 mL	2.5480 mL
	30 mM	0.0849 mL	0.4247 mL	0.8493 mL	2.1234 mL
	40 mM	0.0637 mL	0.3185 mL	0.6370 mL	1.5925 mL
	50 mM	0.0510 mL	0.2548 mL	0.5096 mL	1.2740 mL
	60 mM	0.0425 mL	0.2123 mL	0.4247 mL	1.0617 mL
	80 mM	0.0319 mL	0.1593 mL	0.3185 mL	0.7963 mL
	100 mM	0.0255 mL	0.1274 mL	0.2548 mL	0.6370 mL

Keywords

Dexamethasone (GMP)

4 Cited Publications

100 mg 견적 받기

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Dexamethasone (GMP)

Publications Citing Use of MedChemExpress (MCE) Dexamethasone (GMP)

All ADC Payloads Isoforms

Biological Activity

Chemical Information

Publications (4)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Dexamethasone (GMP) Related Classifications

HY-14648G Related Classifications