DG1
DG1 (Compound 8Nc) is a Thymidylate Synthase (TS) inhibitor that affects cancer angiogenesis and metabolic reprogramming in NSCLC cells. DG1 can effectively inhibit the expression of CD26, ET-1, FGF-1 and EGF. DG1 also effectively inhibits the proliferation of cancer tissue in the A549 xenograft mouse model.
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- 화학식: C19H17N5O5S
- 분자량:427.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.96 μM
Compound: 8Nc; DG1
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
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[PMID: 37437348] |
| BEAS-2B | CC50 |
136.16 μM
Compound: 8Nc; DG1
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Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 37437348] |
| Calu-1 | IC50 |
6.77 μM
Compound: 8Nc; DG1
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Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
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[PMID: 37437348] |
| NCI-H1975 | IC50 |
0.71 μM
Compound: 8Nc; DG1
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Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
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[PMID: 37437348] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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분자량 427.43
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화학식 C19H17N5O5S
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SMILES
O=C1NC(NC=C1S(=O)(NC2=CC=CC(C(N/N=C/C3=CC(C)=CC=C3)=O)=C2)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DG1 Related Classifications
HY-149352 Related Classifications
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