DOPE-PEG2000-A7R

DOPE-PEG2000-A7R: surface modification of liposomes and nanoparticles for tumor vasculature-targeted drug delivery and anti-angiogenic research, by targeting VEGFR-2 on angiogenic endothelial cells.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes pH-responsive membrane fusion for intracellular drug release;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces protein adsorption and immune clearance, and extends circulation half-life;
(3) A7R peptide; a heptapeptide (ATWLPPR) that specifically binds to vascular endothelial growth factor receptor-2 (VEGFR-2), which is highly expressed on angiogenic endothelial cells in tumor vasculature, enabling targeted delivery to tumor blood vessels; A7R also acts as a VEGF antagonist, blocking VEGF-VEGFR2 signaling to inhibit angiogenesis and tumor growth.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.