country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-120667

Copy Link Print Information

DS-5272

DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC₅₀ of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC₅₀=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1235575-97-9
화학식: C₃₄H₃₈Cl₂F₂N₆O₂S
분자량:703.67

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DS-5272 Chemical Structure

CAS No.: 1235575-97-9

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC₅₀: 20 nM (p53-MDM2 interaction)

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	GI₅₀	>50 μM Compound: 8, DS-5272	Antiproliferative activity against human DLD1 cells expressing mutant p53 after 3 days by luminescent cell viability assay Antiproliferative activity against human DLD1 cells expressing mutant p53 after 3 days by luminescent cell viability assay	[PMID: 25882531]
SJSA-1	GI₅₀	0.17 μM Compound: 8, DS-5272	Antiproliferative activity against human SJSA1 cells expressing wildtype p53 after 3 days by luminescent cell viability assay Antiproliferative activity against human SJSA1 cells expressing wildtype p53 after 3 days by luminescent cell viability assay	[PMID: 25882531]

Chemical Information

CAS No. 1235575-97-9
분자량 703.67
화학식 C₃₄H₃₈Cl₂F₂N₆O₂S
SMILES

O=C([C@H]1N(C(C2=C(C(C)C)N3C(S2)=N[C@@](C)(C4=CC=C(Cl)N=C4)[C@H]3C5=CC=C(Cl)C(F)=C5)=O)C[C@H](F)C1)N(C6)[C@H](CC)CNC76CC7
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Miyazaki M, et al., Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor. Bioorg Med Chem. 2015 May 15;23(10):2360-7. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기