DSPE-PEG2000-Mannose
Based on 1 publication(s) in Google Scholar
DSPE-PEG 2000-Mannose is a mannose-containing lipid. DSPE-PEG 2000-Mannose is used to prepare mannose-conjugated Liposome (Man-lipo) for siRNA delivery. Mannose-modified liposomes encapsulating IDO siRNA (Man-lipo-siIDO) preferentially knock down IDO expression in the draining lymph nodes and spleens of melanoma-bearing mice. Man-lipo-siIDO delays the onset time of melanoma and reduces tumor volume.
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- Purity: 90.0%
- CAS No.: 1829524-73-3
- 분자량:2000 (Average)
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DSPE-PEG2000-Mannose
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Biological Activity
DSPE-PEG2000-Mannose (3:10:10:4 molar ratio with DOTAP, DPPC, cholesterol; 10 min hydration, 10 min post-extrusion incubation) was used to prepare mannose-conjugated liposomes (Man-lipo) for siRNA delivery, with formulation steps including lipid mixing, hydration with siRNA-protamine mixture, vortexing, sonication, extrusion, and post-extrusion incubation[1].
DSPE-PEG2000-Mannose-formulated Man-lipo-siIDO (24 h post-transfection) significantly reduced IDO mRNA levels in mouse bone marrow-derived dendritic cells (DCs) compared to Man-lipo-siScramble control[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1829524-73-3
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Appearance Solid
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분자량 2000 (Average)
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCC(O[C@@H](COP(OCCNC(OCCOCCNC(NC1=CC=C(O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=C1)=S)=O)(O)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O.[n]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
용액&용해도
DMSO : 16.67 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
순도&문서
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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