Eribaxaban
Based on 1 Customer Validation
Eribaxaban (PD-0348292) is an orally active and selective FXa inhibitor with a Ki value of 0.32 nM. Eribaxaban reduces thrombus formation.
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- Purity: 98.52%
- CAS No.: 536748-46-6
- 화학식: C24H22ClFN4O4
- 분자량:484.91
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Ki: 0.32 nM (FXa)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four-month-old, pre-estrus, female pigs[2]
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Dosage:0.4, 0.9, 4.3 mg/kg
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Administration:P.o.; four hours prior to thrombus induction
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Result:Significantly reducted carotid platelet deposition, chamber platelet deposition.
Chemical Information
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CAS No. 536748-46-6
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Appearance Solid
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분자량 484.91
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화학식 C24H22ClFN4O4
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Color Light yellow to yellow
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SMILES
O=C(NC(C=C1)=CC=C1Cl)N2[C@H](C[C@@H](OC)C2)C(NC3=CC=C(C=C3F)N(C=CC=C4)C4=O)=O
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Synonyms
PD-0348292
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 125 mg/mL (257.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Eriksson BI, et al. Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development. Clin Pharmacokinet. 2009;48(1):1-22. [Content Brief]
[2]. Karnicki K, et al. Comparison of PD0348292, a selective factor Xa inhibitor, to antiplatelet agents for the inhibition of arterial thrombosis. Thromb Haemost. 2008 Apr;99(4):759-66. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0622 mL | 10.3112 mL | 20.6224 mL | 51.5560 mL |
| 5 mM | 0.4124 mL | 2.0622 mL | 4.1245 mL | 10.3112 mL | |
| 10 mM | 0.2062 mL | 1.0311 mL | 2.0622 mL | 5.1556 mL | |
| 15 mM | 0.1375 mL | 0.6874 mL | 1.3748 mL | 3.4371 mL | |
| 20 mM | 0.1031 mL | 0.5156 mL | 1.0311 mL | 2.5778 mL | |
| 25 mM | 0.0825 mL | 0.4124 mL | 0.8249 mL | 2.0622 mL | |
| 30 mM | 0.0687 mL | 0.3437 mL | 0.6874 mL | 1.7185 mL | |
| 40 mM | 0.0516 mL | 0.2578 mL | 0.5156 mL | 1.2889 mL | |
| 50 mM | 0.0412 mL | 0.2062 mL | 0.4124 mL | 1.0311 mL | |
| 60 mM | 0.0344 mL | 0.1719 mL | 0.3437 mL | 0.8593 mL | |
| 80 mM | 0.0258 mL | 0.1289 mL | 0.2578 mL | 0.6444 mL | |
| 100 mM | 0.0206 mL | 0.1031 mL | 0.2062 mL | 0.5156 mL |
Eribaxaban Related Classifications
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