LPIN1 - lipin 1 Gene

Also Known as PAP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23175

About LPIN1

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:11,677,544-11,827,409 (from NCBI)

This gene has 20 transcripts (splice variants), 273 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 18.7), ovary (RPKM 8.2) and 24 other tissues.

Summary

This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of Other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]

LPIN1 Products (13)

mRNA	Protein	Name
NM_001261427.3	NP_001248356.1	phosphatidate phosphatase LPIN1 isoform 2
NM_001261428.3	NP_001248357.1	phosphatidate phosphatase LPIN1 isoform 3
NM_001349199.2	NP_001336128.1	phosphatidate phosphatase LPIN1 isoform 1
NM_001349200.2	NP_001336129.1	phosphatidate phosphatase LPIN1 isoform 5
NM_001349201.2	NP_001336130.1	phosphatidate phosphatase LPIN1 isoform 5
NM_001349202.2	NP_001336131.1	phosphatidate phosphatase LPIN1 isoform 6
NM_001349203.2	NP_001336132.1	phosphatidate phosphatase LPIN1 isoform 6
NM_001349204.2	NP_001336133.1	phosphatidate phosphatase LPIN1 isoform 7
NM_001349205.2	NP_001336134.1	phosphatidate phosphatase LPIN1 isoform 7
NM_001349206.2	NP_001336135.1	phosphatidate phosphatase LPIN1 isoform 7
NM_001349207.2	NP_001336136.1	phosphatidate phosphatase LPIN1 isoform 8
NM_001349208.2	NP_001336137.1	phosphatidate phosphatase LPIN1 isoform 9
NM_145693.4	NP_663731.1	phosphatidate phosphatase LPIN1 isoform 1

LPIN1 Protein Structure

Lipin_N

LNS2

0
200
400
600
800
890 a.a.

Protein Preferred Names	Protein Names
phosphatidate phosphatase LPIN1

LPIN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LPIN1	Q14693	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	LPIN1	Q14693	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	LPIN1	Q14693	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	LPIN1	Q14693	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	LPIN1	Q14693	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	LPIN1	Q14693	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	LPIN1	Q14693	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	LPIN1	Q14693	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	LPIN1	Q14693	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	LPIN1	Q14693	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	LPIN1	Q14693	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	LPIN1	Q14693	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	LPIN1	Q14693	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	LPIN1	Q14693	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	LPIN1	Q14693	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	LPIN1	Q14693	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	LPIN1	Q14693	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	LPIN1	Q14693	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	LPIN1	Q14693	DBH	Homo sapiens	P09172	Y2H Pooling	32814053
Intra	LPIN1	Q14693	DBH	Homo sapiens	P09172	Validated Y2H	32814053
Intra	LPIN1	Q14693	DBH	Homo sapiens	P09172	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

LPIN1 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P82164	Lipin 1 Antibody (YA1909)	WB, IHC-P, ICC/IF, IP, FC	Human

Related Diseases

Diseases	Alias
Myoglobinuria, Acute Recurrent, Autosomal Recessive	Myoglobinuria, Familial Paroxysmal Paralytic Rhabdomyolysis, Acute Recurrent ARARM Acute Recurrent Rhabdomyolysis Familial Paroxysmal Paralytic Myoglobinuria
Genetic Recurrent Myoglobinuria
Myoglobinuria
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Peroneal Neuropathy	Peroneal Neuropathies
Febrile Seizures, Familial, 5	FEB5 Familial Febrile Seizures 5 Convulsions, Familial Febrile, 5 Familial Febrile Convulsions 5 Febrile Convulsions, Familial, 5
Lipodystrophy, Congenital Generalized, Type 1	Congenital Generalized Lipodystrophy Type 1 Bscl1 CGL1 Berardinelli-Seip Congenital Lipodystrophy, Type 1 Brunzell Syndrome Agpat2-Related Berardinelli-Seip Congenital Lipodystrophy Type 1 Lipodystrophy, Berardinelli-Seip Congenital, Type 1 Brunzell Syndrome, Agpat2-Related Agpat2-Related Brunzell Syndrome Congenital Generalized Lipodystrophy 1 Berardinelli-Seip Syndrome Lipoatrophic Diabetes Lipodystrophy Berardinelli Type Total Lipodystrophy And Acromegaloid Gigantism Lipodystrophy, Generalized, Congenital, Type 1 Familial Generalized Lipodystrophy Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Lipodystrophy, Congenital Generalized, Type 2	Congenital Generalized Lipodystrophy Type 2 CGL2 Berardinelli-Seip Congenital Lipodystrophy Type 2 Berardinelli-Seip Syndrome Brunzell Syndrome Bscl2-Related Total Lipodystrophy And Acromegaloid Gigantism Berardinelli-Seip Congenital Lipodystrophy, Type 2 Seip Syndrome Berardinelli Syndrome Lipodystrophy, Total, And Acromegaloid Gigantism Lipoatrophic Diabetes, Congenital Lipodystrophy, Berardinelli-Seip Congenital, Type 2 Brunzell Syndrome, Bscl2-Related Congenital Lipoatrophic Diabetes Congenital Generalized Lipodystrophy 2 Lipoatrophic Diabetes Lipodystrophy Berardinelli Type Familial Generalized Lipodystrophy Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Inflammatory Bowel Disease 27	IBD27
Complete Generalized Lipodystrophy
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Achalasia	Cardiospasm Achalasia Of Cardia Esophageal Achalasia Hypertensive Lower Esophageal Sphincter Idiopathic Achalasia Achalasia Cardia Idiopathic Achalasia Of Esophagus Primary Achalasia Achalasia Of Esophagus Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter Aperistalsis Of The Oesophagus Achalasia Of Oesophagus Oesophageal Achalasia Achalasia Nos Cardia Spasm Cardia Achalasia Oesophageal Cardiospasm Oesophagus Achalasia Reflex Cardiospasm
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Chanarin-Dorfman Syndrome	Neutral Lipid Storage Disease CDS Neutral Lipid Storage Disease With Ichthyosis Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation Triglyceride Storage Disease With Ichthyosis Nlsdi Ichthyotic Neutral Lipid Storage Disease Dorfman-Chanarin Syndrome Dcs Chanarin-Dorfman Disease Ichthyosiform Erythroderma With Leukocyte Vacuolation Lipidosis With Triglyceride Storage Disease Disorder Of Cornification 12 Dorfman Chanarin Syndrome Neutral Lipid Storage Disease With Ichthyotic Dorfman-Chanarin Disease
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS19455	Lpin1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07769	LPIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25948	Lpin1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LPIN1	VGNC	VGNC:42751
Rattus norvegicus	LPIN1	RGD	RGD:1307646
Macaca mulatta	LPIN1	VGNC	VGNC:74278
Felis catus	LPIN1	VGNC	VGNC:63268
Mus musculus	LPIN1	MGD	MGI:1891340
Bos taurus	LPIN1	VGNC	VGNC:30966
Others	LPIN1	NCBI